Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor
The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2014/424790 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556246566174720 |
|---|---|
| author | Lin-jie Liu Xia Gao Pei Zhang Shi-lan Feng Fang-di Hu Ying-dong Li Chun-ming Wang |
| author_facet | Lin-jie Liu Xia Gao Pei Zhang Shi-lan Feng Fang-di Hu Ying-dong Li Chun-ming Wang |
| author_sort | Lin-jie Liu |
| collection | DOAJ |
| description | The electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated. Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of 8.95×10-8 M ~5.29×10-5 M, with a relatively low detection limit of 4.42×10-8 M. This fabricated sensor also displayed acceptable reproducibility, long-term stability, and high selectivity with negligible interferences from common interfering species. Besides, it was applied to detect FA in Angelica sinensis and biological samples with satisfactory results, making it a potential alternative tool for the quantitative detection of FA in pharmaceutical analysis. |
| format | Article |
| id | doaj-art-42a378a31e044c20938bbd70c2bd7694 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-42a378a31e044c20938bbd70c2bd76942025-02-03T05:45:56ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732014-01-01201410.1155/2014/424790424790Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical SensorLin-jie Liu0Xia Gao1Pei Zhang2Shi-lan Feng3Fang-di Hu4Ying-dong Li5Chun-ming Wang6School of Pharmacy, Lanzhou University, Lanzhou 730000, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou 730000, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou 730000, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou 730000, ChinaSchool of Pharmacy, Lanzhou University, Lanzhou 730000, ChinaGansu College of Traditional Chinese Medicine, Lanzhou 730000, ChinaDepartment of Chemistry, Lanzhou University, Lanzhou 730000, ChinaThe electrochemical redox of ferulic acid (FA) was investigated systematically by cyclic voltammetry (CV) with a poly(diallyldimethylammonium chloride) functionalized graphene-modified glassy carbon electrode (PDDA-G/GCE) as a working electrode. A simple and sensitive differential pulse voltammetry (DPV) technique was proposed for the direct quantitative determination of FA in Angelica sinensis and spiked human urine samples for the first time. The dependence of the intensities of currents and potentials on nature of the supporting electrolyte, pH, scan rate, and concentration was investigated. Under optimal conditions, the proposed sensor exhibited excellent electrochemical sensitivity to FA, and the oxidation peak current was proportional to FA concentration in the range of 8.95×10-8 M ~5.29×10-5 M, with a relatively low detection limit of 4.42×10-8 M. This fabricated sensor also displayed acceptable reproducibility, long-term stability, and high selectivity with negligible interferences from common interfering species. Besides, it was applied to detect FA in Angelica sinensis and biological samples with satisfactory results, making it a potential alternative tool for the quantitative detection of FA in pharmaceutical analysis.http://dx.doi.org/10.1155/2014/424790 |
| spellingShingle | Lin-jie Liu Xia Gao Pei Zhang Shi-lan Feng Fang-di Hu Ying-dong Li Chun-ming Wang Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor Journal of Analytical Methods in Chemistry |
| title | Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor |
| title_full | Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor |
| title_fullStr | Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor |
| title_full_unstemmed | Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor |
| title_short | Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor |
| title_sort | ultrasensitive detection of ferulic acid using poly diallyldimethylammonium chloride functionalized graphene based electrochemical sensor |
| url | http://dx.doi.org/10.1155/2014/424790 |
| work_keys_str_mv | AT linjieliu ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT xiagao ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT peizhang ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT shilanfeng ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT fangdihu ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT yingdongli ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor AT chunmingwang ultrasensitivedetectionofferulicacidusingpolydiallyldimethylammoniumchloridefunctionalizedgraphenebasedelectrochemicalsensor |