An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches

Diabetic Retinopathy is a progressive microvascular complication of diabetes that requires early detection to improve patient outcomes. Traditional screening techniques, including fundus photography and optical coherence tomography, provide valuable diagnostic insights but have some limitations, lik...

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Main Authors: Malaika Asif, Fasih Ur Rehman, Zoya Rashid, Altaf Hussain, Alina Mirza, Waqar Shahid Qureshi
Format: Article
Language:English
Published: IEEE 2025-01-01
Series:IEEE Access
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Online Access:https://ieeexplore.ieee.org/document/11053490/
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author Malaika Asif
Fasih Ur Rehman
Zoya Rashid
Altaf Hussain
Alina Mirza
Waqar Shahid Qureshi
author_facet Malaika Asif
Fasih Ur Rehman
Zoya Rashid
Altaf Hussain
Alina Mirza
Waqar Shahid Qureshi
author_sort Malaika Asif
collection DOAJ
description Diabetic Retinopathy is a progressive microvascular complication of diabetes that requires early detection to improve patient outcomes. Traditional screening techniques, including fundus photography and optical coherence tomography, provide valuable diagnostic insights but have some limitations, like cost and technical complexity. Artificial intelligence is transforming the detection of diabetic retinopathy, moving away from traditional machine learning models that rely on manually created features to deep learning methods that allow for automatic feature extraction from retinal images. This systematic review investigates the evolution and diagnostic performance of AI-based techniques for DR detection. Studies were included if they applied machine learning or deep learning methods to retinal fundus or OCT images for DR classification. A total of 116 studies were included following comprehensive searches in databases such as PubMed, ScienceDirect, and IEEE Xplore, covering publications up to February 2024. Risk of bias was assessed in a representative sample of six studies, indicating a significant overall risk due to inadequate reporting on blinding and selective outcome reporting. Federated learning emerged as a promising alternative, enabling decentralized collaboration without compromising data privacy. Additionally, the growing focus on Explainable AI helps address the “non-explainable” nature of deep learning models by providing visual and textual explanations for predictions, thereby enhancing clinician trust and facilitating informed decision-making. By incorporating artificial intelligence with standard diagnostic frameworks, this research highlights the possibility for more accurate, scalable, and reachable diabetic retinopathy detection, paving the way for considerable advancements in ophthalmic problem management and enhancing patient care.
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issn 2169-3536
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spelling doaj-art-429fd48311f94fa7a2e4db47a9486c4a2025-08-20T03:29:03ZengIEEEIEEE Access2169-35362025-01-011311686911688610.1109/ACCESS.2025.358364711053490An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven ApproachesMalaika Asif0Fasih Ur Rehman1https://orcid.org/0009-0008-6164-7437Zoya Rashid2https://orcid.org/0009-0009-5918-6720Altaf Hussain3https://orcid.org/0000-0002-0558-1380Alina Mirza4https://orcid.org/0000-0001-7227-253XWaqar Shahid Qureshi5https://orcid.org/0000-0003-0176-8145Department of Computer Science, Institute of Space Technology, KICSIT Campus, Islamabad, PakistanDepartment of Computer Science, Institute of Space Technology, KICSIT Campus, Islamabad, PakistanDepartment of Computer Science, Institute of Space Technology, KICSIT Campus, Islamabad, PakistanDepartment of Computer Science, Institute of Space Technology, KICSIT Campus, Islamabad, PakistanElectrical Engineering Department, National University of Sciences and Technology, Islamabad, PakistanSchool of Computer Science, University of Galway, Galway, IrelandDiabetic Retinopathy is a progressive microvascular complication of diabetes that requires early detection to improve patient outcomes. Traditional screening techniques, including fundus photography and optical coherence tomography, provide valuable diagnostic insights but have some limitations, like cost and technical complexity. Artificial intelligence is transforming the detection of diabetic retinopathy, moving away from traditional machine learning models that rely on manually created features to deep learning methods that allow for automatic feature extraction from retinal images. This systematic review investigates the evolution and diagnostic performance of AI-based techniques for DR detection. Studies were included if they applied machine learning or deep learning methods to retinal fundus or OCT images for DR classification. A total of 116 studies were included following comprehensive searches in databases such as PubMed, ScienceDirect, and IEEE Xplore, covering publications up to February 2024. Risk of bias was assessed in a representative sample of six studies, indicating a significant overall risk due to inadequate reporting on blinding and selective outcome reporting. Federated learning emerged as a promising alternative, enabling decentralized collaboration without compromising data privacy. Additionally, the growing focus on Explainable AI helps address the “non-explainable” nature of deep learning models by providing visual and textual explanations for predictions, thereby enhancing clinician trust and facilitating informed decision-making. By incorporating artificial intelligence with standard diagnostic frameworks, this research highlights the possibility for more accurate, scalable, and reachable diabetic retinopathy detection, paving the way for considerable advancements in ophthalmic problem management and enhancing patient care.https://ieeexplore.ieee.org/document/11053490/Diabetic retinopathyophthalmologistsconvolutional neural networkretina fundus
spellingShingle Malaika Asif
Fasih Ur Rehman
Zoya Rashid
Altaf Hussain
Alina Mirza
Waqar Shahid Qureshi
An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
IEEE Access
Diabetic retinopathy
ophthalmologists
convolutional neural network
retina fundus
title An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
title_full An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
title_fullStr An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
title_full_unstemmed An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
title_short An Insight on the Timely Diagnosis of Diabetic Retinopathy Using Traditional and AI-Driven Approaches
title_sort insight on the timely diagnosis of diabetic retinopathy using traditional and ai driven approaches
topic Diabetic retinopathy
ophthalmologists
convolutional neural network
retina fundus
url https://ieeexplore.ieee.org/document/11053490/
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