Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies
Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis occurring in individuals under 18 years of age. It is characterized by poor cognitive outcomes and a more inflammatory course, more frequent clinical relapses, and a greater number of MRI lesions compared to adult-onset MS (AOMS)...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Neurotherapeutics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878747925001096 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849237601954824192 |
|---|---|
| author | Lama Saleh Aljomah E. Ann Yeh |
| author_facet | Lama Saleh Aljomah E. Ann Yeh |
| author_sort | Lama Saleh Aljomah |
| collection | DOAJ |
| description | Pediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis occurring in individuals under 18 years of age. It is characterized by poor cognitive outcomes and a more inflammatory course, more frequent clinical relapses, and a greater number of MRI lesions compared to adult-onset MS (AOMS). Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change the trajectory of disease progression. In this paper, we will review diagnostic criteria for pediatric multiple sclerosis, differential diagnosis, and current and emerging therapeutic approaches. While a number of DMTs are approved for adult MS, few are approved for pediatric use. Many of these DMTs are used off-label, with real-world evidence demonstrating their effectiveness and safety. The review evaluates existing evidence for the use of these therapies in pediatric populations, with an emphasis on both existing clinical trials and real-world data that supports their use. In addition, we will briefly highlight ongoing clinical trials and emerging therapies for POMS. |
| format | Article |
| id | doaj-art-429d2d4f7b3446d5bf826126e8e66bd0 |
| institution | Kabale University |
| issn | 1878-7479 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurotherapeutics |
| spelling | doaj-art-429d2d4f7b3446d5bf826126e8e66bd02025-08-20T04:01:56ZengElsevierNeurotherapeutics1878-74792025-07-01224e0063110.1016/j.neurot.2025.e00631Pediatric multiple sclerosis: Improving outcome through high-efficacy therapiesLama Saleh Aljomah0E. Ann Yeh1Department of Pediatrics (Neurology), SickKids Research Institute, Division of Neurosciences and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, CanadaCorresponding author.; Department of Pediatrics (Neurology), SickKids Research Institute, Division of Neurosciences and Mental Health, Hospital for Sick Children, University of Toronto, Toronto, CanadaPediatric-onset multiple sclerosis (POMS) refers to multiple sclerosis occurring in individuals under 18 years of age. It is characterized by poor cognitive outcomes and a more inflammatory course, more frequent clinical relapses, and a greater number of MRI lesions compared to adult-onset MS (AOMS). Prompt recognition of multiple sclerosis in this population is essential, as early intervention with disease-modifying therapies may change the trajectory of disease progression. In this paper, we will review diagnostic criteria for pediatric multiple sclerosis, differential diagnosis, and current and emerging therapeutic approaches. While a number of DMTs are approved for adult MS, few are approved for pediatric use. Many of these DMTs are used off-label, with real-world evidence demonstrating their effectiveness and safety. The review evaluates existing evidence for the use of these therapies in pediatric populations, with an emphasis on both existing clinical trials and real-world data that supports their use. In addition, we will briefly highlight ongoing clinical trials and emerging therapies for POMS.http://www.sciencedirect.com/science/article/pii/S1878747925001096Pediatric-onset multiple sclerosisDemyelinating diseaseDisease-modifying therapy |
| spellingShingle | Lama Saleh Aljomah E. Ann Yeh Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies Neurotherapeutics Pediatric-onset multiple sclerosis Demyelinating disease Disease-modifying therapy |
| title | Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies |
| title_full | Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies |
| title_fullStr | Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies |
| title_full_unstemmed | Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies |
| title_short | Pediatric multiple sclerosis: Improving outcome through high-efficacy therapies |
| title_sort | pediatric multiple sclerosis improving outcome through high efficacy therapies |
| topic | Pediatric-onset multiple sclerosis Demyelinating disease Disease-modifying therapy |
| url | http://www.sciencedirect.com/science/article/pii/S1878747925001096 |
| work_keys_str_mv | AT lamasalehaljomah pediatricmultiplesclerosisimprovingoutcomethroughhighefficacytherapies AT eannyeh pediatricmultiplesclerosisimprovingoutcomethroughhighefficacytherapies |