Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates

Tripeptide DT-109 (Gly-Gly-Leu) attenuates atherosclerosis and vascular calcification in nonhuman primates

Abstract Advanced atherosclerotic lesions and vascular calcification substantially increase the risk of cardiovascular events. However, effective strategies for preventing or treating advanced atherosclerosis and calcification are currently lacking. This study investigated the efficacy of DT-109 (Gl...

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Main Authors: Linying Jia, Pengxiang Qu, Yang Zhao, Liang Bai, Honghao Ren, Ao Cheng, Zeyao Ma, Cheng Ding, Yongjie Deng, Lingxuan Kong, Ying Zhao, Oren Rom, Yajie Chen, Naqash Alam, Wenbin Cao, Sixue Zhai, Zuowen Zheng, Zhi Hu, Lu Wang, Yabing Chen, Sihai Zhao, Jifeng Zhang, Jianglin Fan, Y. Eugene Chen, Enqi Liu
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02201-2
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