Mortality of Post-COVID-19 Condition: 2025 Update
Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of post-COVID-19...
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MDPI AG
2025-01-01
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| Series: | COVID |
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| Online Access: | https://www.mdpi.com/2673-8112/5/1/11 |
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| author | Giuseppe Lippi Fabian Sanchis-Gomar |
| author_facet | Giuseppe Lippi Fabian Sanchis-Gomar |
| author_sort | Giuseppe Lippi |
| collection | DOAJ |
| description | Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of post-COVID-19 mortality is therefore critical for effective healthcare planning and resource allocation. Methods: A descriptive epidemiological study was conducted using data from the US National Center for Health Statistics 2018–2024 to identify deaths attributed to the post-COVID-19 condition, as classified by the ICD-10 code U09.9, from October 2021 to December 2024. Demographic factors such as gender, age, and place of death were also extracted. Results: By December 2024, 2653 US deaths were classified under the ICD-10 code U09.9, corresponding to an age-adjusted mortality rate of 0.089 × 100,000. Mortality was significantly higher in males compared to females (0.098 vs. 0.081 × 100,000; <i>p</i> < 0.001). A clear age-related mortality gradient was observed, with rates increasing almost linearly with advancing age. The largest fraction of post-COVID-19 deaths occurred at home (33.0%), followed by nursing homes (26.3%) and medical facilities (24.1%). Conclusions: These findings highlight the substantial yet complex impact of the post-COVID-19 condition on mortality, with higher rates observed in males, older adults, and individuals at home, highlighting the need for targeted healthcare interventions and resource allocation, particularly for these higher-risk groups. |
| format | Article |
| id | doaj-art-4296ad7edc044612916c635ec189812d |
| institution | Kabale University |
| issn | 2673-8112 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | COVID |
| spelling | doaj-art-4296ad7edc044612916c635ec189812d2025-01-24T13:27:58ZengMDPI AGCOVID2673-81122025-01-01511110.3390/covid5010011Mortality of Post-COVID-19 Condition: 2025 UpdateGiuseppe Lippi0Fabian Sanchis-Gomar1Section of Clinical Biochemistry, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, ItalyDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, 450 Jane Stanford Way, Stanford, CA 94305, USABackground: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of post-COVID-19 mortality is therefore critical for effective healthcare planning and resource allocation. Methods: A descriptive epidemiological study was conducted using data from the US National Center for Health Statistics 2018–2024 to identify deaths attributed to the post-COVID-19 condition, as classified by the ICD-10 code U09.9, from October 2021 to December 2024. Demographic factors such as gender, age, and place of death were also extracted. Results: By December 2024, 2653 US deaths were classified under the ICD-10 code U09.9, corresponding to an age-adjusted mortality rate of 0.089 × 100,000. Mortality was significantly higher in males compared to females (0.098 vs. 0.081 × 100,000; <i>p</i> < 0.001). A clear age-related mortality gradient was observed, with rates increasing almost linearly with advancing age. The largest fraction of post-COVID-19 deaths occurred at home (33.0%), followed by nursing homes (26.3%) and medical facilities (24.1%). Conclusions: These findings highlight the substantial yet complex impact of the post-COVID-19 condition on mortality, with higher rates observed in males, older adults, and individuals at home, highlighting the need for targeted healthcare interventions and resource allocation, particularly for these higher-risk groups.https://www.mdpi.com/2673-8112/5/1/11post COVIDlong COVIDmortalitydeath |
| spellingShingle | Giuseppe Lippi Fabian Sanchis-Gomar Mortality of Post-COVID-19 Condition: 2025 Update COVID post COVID long COVID mortality death |
| title | Mortality of Post-COVID-19 Condition: 2025 Update |
| title_full | Mortality of Post-COVID-19 Condition: 2025 Update |
| title_fullStr | Mortality of Post-COVID-19 Condition: 2025 Update |
| title_full_unstemmed | Mortality of Post-COVID-19 Condition: 2025 Update |
| title_short | Mortality of Post-COVID-19 Condition: 2025 Update |
| title_sort | mortality of post covid 19 condition 2025 update |
| topic | post COVID long COVID mortality death |
| url | https://www.mdpi.com/2673-8112/5/1/11 |
| work_keys_str_mv | AT giuseppelippi mortalityofpostcovid19condition2025update AT fabiansanchisgomar mortalityofpostcovid19condition2025update |