Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition
IntroductionRapid dietary transition in dogs can disturb the balance of gut microbiota, resulting in symptoms such as diarrhea and compromised immune function. Yeast probiotic (Saccharomyces cerevisiae), has been shown to improve intestinal microbial composition and stimulate immune function. This s...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1561660/full |
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| author | Jia Xu Jia Xu Chaoyu Wen Guangming Song Achraf Adib Lesaux Hao Zhang Yu Luo |
| author_facet | Jia Xu Jia Xu Chaoyu Wen Guangming Song Achraf Adib Lesaux Hao Zhang Yu Luo |
| author_sort | Jia Xu |
| collection | DOAJ |
| description | IntroductionRapid dietary transition in dogs can disturb the balance of gut microbiota, resulting in symptoms such as diarrhea and compromised immune function. Yeast probiotic (Saccharomyces cerevisiae), has been shown to improve intestinal microbial composition and stimulate immune function. This study aims to investigate the effects of yeast probiotic Saccharomyces cerevisiae supplementation on hematology, serum biochemistry, fecal IgA, microbiota, and metabolites in dogs undergoing rapid dietary transition.MethodsTwenty healthy adult dogs were allocated into two groups: the control group (CON) and the yeast probiotic supplementation (YPS). All dogs were initially fed Diet 1 for 4 weeks, followed by an abrupt switch to Diet 2 for another 4 weeks. Throughout the study, the YPS group received 0.1% Actisaf® Sc 50 product in a capsule given with their food, while the control group received a placebo.ResultsCompared to the CON group, the YPS group exhibited lower serum globulin levels and higher albumin-to-globulin ratios on days 28 and 56 (p < 0.05). On day 56, the YPS group showed lower white blood cell counts and lower serum glucose levels (p < 0.05). Fecal IgA concentrations were higher in the YPS group on days 28, 30, 42, and 56 (p < 0.05). In the CON group, the abundance of Firmicutes significantly increased and the abundance of Fusobacteriota and Bacteroidota significantly decreased on days 42 compared to day 28 (q < 0.05). The YPS group showed a more stable gut microbiota transition post-dietary change. In the CON group, no significant changes in metabolite composition were observed 2 days after the dietary transition, but notable changes appeared after 2 weeks. In contrast, the YPS group exhibited substantial changes in metabolite composition 2 days after the diet change. Tyrosine metabolism showed significant changes in both groups of dogs following the dietary transition.ConclusionSaccharomyces cerevisiae supplementation during rapid dietary transition in dogs led to beneficial changes in blood parameters, increased fecal IgA levels, and promoted a more stable gut microbiota. These findings suggest that yeast probiotics may support gut health and immune function during periods of dietary change. |
| format | Article |
| id | doaj-art-42937a9d3bb14994ac869af9b5d1085c |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-42937a9d3bb14994ac869af9b5d1085c2025-08-20T03:10:06ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15616601561660Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transitionJia Xu0Jia Xu1Chaoyu Wen2Guangming Song3Achraf Adib Lesaux4Hao Zhang5Yu Luo6Department of Veterinary Medicine, Faculty of Agriculture, Jinhua University and Vocational Technology, Jinhua, ChinaHaite Pet Nutrition & Health Institute, Hangzhou, ChinaHaite Pet Nutrition & Health Institute, Hangzhou, ChinaLesaffre Management (Shanghai) Co., Ltd., Shanghai, ChinaPhileo by Lesaffre, Marcq-en-Baroeul, FranceLesaffre Management (Shanghai) Co., Ltd., Shanghai, ChinaDepartment of Veterinary Medicine, Faculty of Agriculture, Jinhua University and Vocational Technology, Jinhua, ChinaIntroductionRapid dietary transition in dogs can disturb the balance of gut microbiota, resulting in symptoms such as diarrhea and compromised immune function. Yeast probiotic (Saccharomyces cerevisiae), has been shown to improve intestinal microbial composition and stimulate immune function. This study aims to investigate the effects of yeast probiotic Saccharomyces cerevisiae supplementation on hematology, serum biochemistry, fecal IgA, microbiota, and metabolites in dogs undergoing rapid dietary transition.MethodsTwenty healthy adult dogs were allocated into two groups: the control group (CON) and the yeast probiotic supplementation (YPS). All dogs were initially fed Diet 1 for 4 weeks, followed by an abrupt switch to Diet 2 for another 4 weeks. Throughout the study, the YPS group received 0.1% Actisaf® Sc 50 product in a capsule given with their food, while the control group received a placebo.ResultsCompared to the CON group, the YPS group exhibited lower serum globulin levels and higher albumin-to-globulin ratios on days 28 and 56 (p < 0.05). On day 56, the YPS group showed lower white blood cell counts and lower serum glucose levels (p < 0.05). Fecal IgA concentrations were higher in the YPS group on days 28, 30, 42, and 56 (p < 0.05). In the CON group, the abundance of Firmicutes significantly increased and the abundance of Fusobacteriota and Bacteroidota significantly decreased on days 42 compared to day 28 (q < 0.05). The YPS group showed a more stable gut microbiota transition post-dietary change. In the CON group, no significant changes in metabolite composition were observed 2 days after the dietary transition, but notable changes appeared after 2 weeks. In contrast, the YPS group exhibited substantial changes in metabolite composition 2 days after the diet change. Tyrosine metabolism showed significant changes in both groups of dogs following the dietary transition.ConclusionSaccharomyces cerevisiae supplementation during rapid dietary transition in dogs led to beneficial changes in blood parameters, increased fecal IgA levels, and promoted a more stable gut microbiota. These findings suggest that yeast probiotics may support gut health and immune function during periods of dietary change.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1561660/fullcaninegut microbiotametabolomicsSaccharomyces cerevisiaeprobiotics |
| spellingShingle | Jia Xu Jia Xu Chaoyu Wen Guangming Song Achraf Adib Lesaux Hao Zhang Yu Luo Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition Frontiers in Microbiology canine gut microbiota metabolomics Saccharomyces cerevisiae probiotics |
| title | Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| title_full | Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| title_fullStr | Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| title_full_unstemmed | Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| title_short | Effect of yeast probiotic Saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| title_sort | effect of yeast probiotic saccharomyces cerevisiae on the gut health of dogs undergoing rapid dietary transition |
| topic | canine gut microbiota metabolomics Saccharomyces cerevisiae probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1561660/full |
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