Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures

Epiplakin expression is lost in psoriatic skin lesions and is downregulated by IFN-γ in ex vivo skin cultures

Proteins of the plakin family are predominantly expressed in the epidermis and play a crucial role in cytoskeletal assembly by crosslinking intracellular structural components with cell–cell junctions and the plasma membrane. While most plakins are critical for maintaining epidermal integrity, the r...

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Bibliographic Details
Main Authors: Hannes Kühtreiber, Corinne Drexler, Melanie Salek, Lisa Auer, Johannes Griss, Michael Mildner, Peter Fuchs
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
plakins
epiplakin
psoriasis
atopic dermatitis
scRNAseq
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1617737/full
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