A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement.
Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this ref...
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Public Library of Science (PLoS)
2007-03-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050061&type=printable |
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| author | Daniel A Butts Patrick O Kanold Carla J Shatz |
| author_facet | Daniel A Butts Patrick O Kanold Carla J Shatz |
| author_sort | Daniel A Butts |
| collection | DOAJ |
| description | Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeniculate synapses have a novel learning rule that depends on the latencies between pre- and postsynaptic bursts on the order of one second: coincident bursts produce long-lasting synaptic enhancement, whereas non-overlapping bursts produce mild synaptic weakening. It is consistent with "Hebbian" development thought to exist at this synapse, and we demonstrate computationally that such a rule can robustly use retinal waves to drive eye segregation and retinotopic refinement. Thus, by measuring plasticity induced by natural activity patterns, synaptic learning rules can be linked directly to their larger role in instructing the patterning of neural connectivity. |
| format | Article |
| id | doaj-art-428e7c9693054480ba06ac58703b5c19 |
| institution | OA Journals |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2007-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-428e7c9693054480ba06ac58703b5c192025-08-20T02:00:50ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852007-03-0153e6110.1371/journal.pbio.0050061A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement.Daniel A ButtsPatrick O KanoldCarla J ShatzPatterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeniculate synapses have a novel learning rule that depends on the latencies between pre- and postsynaptic bursts on the order of one second: coincident bursts produce long-lasting synaptic enhancement, whereas non-overlapping bursts produce mild synaptic weakening. It is consistent with "Hebbian" development thought to exist at this synapse, and we demonstrate computationally that such a rule can robustly use retinal waves to drive eye segregation and retinotopic refinement. Thus, by measuring plasticity induced by natural activity patterns, synaptic learning rules can be linked directly to their larger role in instructing the patterning of neural connectivity.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050061&type=printable |
| spellingShingle | Daniel A Butts Patrick O Kanold Carla J Shatz A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. PLoS Biology |
| title | A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. |
| title_full | A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. |
| title_fullStr | A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. |
| title_full_unstemmed | A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. |
| title_short | A burst-based "Hebbian" learning rule at retinogeniculate synapses links retinal waves to activity-dependent refinement. |
| title_sort | burst based hebbian learning rule at retinogeniculate synapses links retinal waves to activity dependent refinement |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.0050061&type=printable |
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