SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION

Abstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, reg...

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Main Authors: A. A. Savchenko, V. B. Tskhay, D. Yu. Kruglova, A. G. Borisov
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
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Online Access:https://www.mimmun.ru/mimmun/article/view/348
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author A. A. Savchenko
V. B. Tskhay
D. Yu. Kruglova
A. G. Borisov
author_facet A. A. Savchenko
V. B. Tskhay
D. Yu. Kruglova
A. G. Borisov
author_sort A. A. Savchenko
collection DOAJ
description Abstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, regardless of severity of pathological changes in uterine cervix, the women with HPV infection show decreased numbers of NK cells and CD4+ lymphocytes in peripheral blood, along with increased contents of gd T cells. In cases of combined sub-clinical infection with leukoplakia and endocervicosis, more severe disorders of cellular immunity were detectable than in CIN I and CIN II. It is assumed, that initial neoplastic processes with HPV background are accompanied by a more pronounced immune response. Meanwhile, functional activity of neutrophilic granulocytes varies in an inverse manner, being, generally, increased in common HPV infection, followed by most significant changes in CIN I and CIN II.
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institution Kabale University
issn 1563-0625
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language Russian
publishDate 2014-07-01
publisher St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
record_format Article
series Медицинская иммунология
spelling doaj-art-428d6b6c1f424ad5bcf01095a6b40f032025-08-20T03:37:46ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0114320721210.15789/1563-0625-2012-3-207-212345SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTIONA. A. Savchenko0V. B. Tskhay1D. Yu. Kruglova2A. G. Borisov3НИИ медицинских проблем Севера СО РАМН, г. Красноярск Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого Минздрава РФ, г. КрасноярскКрасноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого Минздрава РФ, г. КрасноярскНИИ медицинских проблем Севера СО РАМН, г. Красноярск Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого Минздрава РФ, г. КрасноярскНИИ медицинских проблем Севера СО РАМН, г. КрасноярскAbstract. To study immunological indices and functional activity of neutrophils in women with human papillomavirus infection (HPV), as well as their dependence on severity of cervical morphological alterations, we examined sixty-seven female patients in their reproductive age. It was found that, regardless of severity of pathological changes in uterine cervix, the women with HPV infection show decreased numbers of NK cells and CD4+ lymphocytes in peripheral blood, along with increased contents of gd T cells. In cases of combined sub-clinical infection with leukoplakia and endocervicosis, more severe disorders of cellular immunity were detectable than in CIN I and CIN II. It is assumed, that initial neoplastic processes with HPV background are accompanied by a more pronounced immune response. Meanwhile, functional activity of neutrophilic granulocytes varies in an inverse manner, being, generally, increased in common HPV infection, followed by most significant changes in CIN I and CIN II.https://www.mimmun.ru/mimmun/article/view/348lymphocytesneutrophilic granulocytespapillomavirus infectionsub-clinical formsleukoplakiadysplasia
spellingShingle A. A. Savchenko
V. B. Tskhay
D. Yu. Kruglova
A. G. Borisov
SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
Медицинская иммунология
lymphocytes
neutrophilic granulocytes
papillomavirus infection
sub-clinical forms
leukoplakia
dysplasia
title SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_fullStr SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_full_unstemmed SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_short SOME IMMUNOLOGICAL INDICATORS IN CERVICAL PATHOLOGY ASSOCIATED WITH PAPILLOMAVIRUS INFECTION
title_sort some immunological indicators in cervical pathology associated with papillomavirus infection
topic lymphocytes
neutrophilic granulocytes
papillomavirus infection
sub-clinical forms
leukoplakia
dysplasia
url https://www.mimmun.ru/mimmun/article/view/348
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