Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study
Background To evaluate the mortality patterns of SLE and the associated risk factors in Koreans.Methods Using the National Health Insurance database spanning 2008 to 2018, incident cases of SLE in patients aged 10–79 years were included. We analysed the all-cause mortality and cause-specific mortali...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
|
| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/12/1/e001361.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850023627653644288 |
|---|---|
| author | Sun-Young Jung Yoon-Kyoung Sung Soo-Kyung Cho Eun Jin Jang Yena Jeon Jung-hyo Kim |
| author_facet | Sun-Young Jung Yoon-Kyoung Sung Soo-Kyung Cho Eun Jin Jang Yena Jeon Jung-hyo Kim |
| author_sort | Sun-Young Jung |
| collection | DOAJ |
| description | Background To evaluate the mortality patterns of SLE and the associated risk factors in Koreans.Methods Using the National Health Insurance database spanning 2008 to 2018, incident cases of SLE in patients aged 10–79 years were included. We analysed the all-cause mortality and cause-specific mortality, stratifying by sex and age. The mortality rate (MR) was calculated as the number of deaths per 100 000 person-years (PYs). The causes of death were identified by the International Classification of Diseases, 10th Revision codes during hospitalisation or emergency visit prior to death. A generalised estimating equation model was employed for risk factor analysis.Results In total, 11 375 incident SLE cases among patients with an average age of 42.3±16.7 years were recruited (86.1% female). During 57 658 PYs, 728 deaths occurred (MR 1262.62/100 000 PYs). The MR among men (2718.86/100 000 PYs) exceeded that among women (1060.57/100 000 PYs). The leading causes of death were SLE-related conditions (381.56/100 000 PYs), cardiovascular disease (CVD) (202.92/100 000 PYs), cancer (175.17/100 000 PYs) and infection (143.95/100 000 PYs). Of the SLE-related mortality, the key risk factors were pulmonary complications, such as pulmonary alveolar haemorrhage (OR 9.93), pulmonary arterial hypertension (OR 3.77) and interstitial lung disease (OR 3.27).Conclusions Among Korean patients with SLE, SLE-related conditions were the leading causes of mortality. However, CVD and cancer were also identified as the main causes of mortality. Furthermore, pulmonary manifestations were significantly associated with SLE-related mortality. |
| format | Article |
| id | doaj-art-428a5bdcabd94341bcb5a1e1544d4384 |
| institution | DOAJ |
| issn | 2053-8790 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj-art-428a5bdcabd94341bcb5a1e1544d43842025-08-20T03:01:19ZengBMJ Publishing GroupLupus Science and Medicine2053-87902025-02-0112110.1136/lupus-2024-001361Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort studySun-Young Jung0Yoon-Kyoung Sung1Soo-Kyung Cho2Eun Jin Jang3Yena Jeon4Jung-hyo Kim5College of Pharmacy, Chung-Ang University, Seoul, Korea (the Republic of)Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seongdong-gu, Korea (the Republic of)Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seongdong-gu, Korea (the Republic of)Department of Data Science, Andong National University, Andong, Korea (the Republic of)Department of Statistics, Kyungpook National University, Daegu, Korea (the Republic of)Department of Data Science, Andong National University, Andong, Korea (the Republic of)Background To evaluate the mortality patterns of SLE and the associated risk factors in Koreans.Methods Using the National Health Insurance database spanning 2008 to 2018, incident cases of SLE in patients aged 10–79 years were included. We analysed the all-cause mortality and cause-specific mortality, stratifying by sex and age. The mortality rate (MR) was calculated as the number of deaths per 100 000 person-years (PYs). The causes of death were identified by the International Classification of Diseases, 10th Revision codes during hospitalisation or emergency visit prior to death. A generalised estimating equation model was employed for risk factor analysis.Results In total, 11 375 incident SLE cases among patients with an average age of 42.3±16.7 years were recruited (86.1% female). During 57 658 PYs, 728 deaths occurred (MR 1262.62/100 000 PYs). The MR among men (2718.86/100 000 PYs) exceeded that among women (1060.57/100 000 PYs). The leading causes of death were SLE-related conditions (381.56/100 000 PYs), cardiovascular disease (CVD) (202.92/100 000 PYs), cancer (175.17/100 000 PYs) and infection (143.95/100 000 PYs). Of the SLE-related mortality, the key risk factors were pulmonary complications, such as pulmonary alveolar haemorrhage (OR 9.93), pulmonary arterial hypertension (OR 3.77) and interstitial lung disease (OR 3.27).Conclusions Among Korean patients with SLE, SLE-related conditions were the leading causes of mortality. However, CVD and cancer were also identified as the main causes of mortality. Furthermore, pulmonary manifestations were significantly associated with SLE-related mortality.https://lupus.bmj.com/content/12/1/e001361.full |
| spellingShingle | Sun-Young Jung Yoon-Kyoung Sung Soo-Kyung Cho Eun Jin Jang Yena Jeon Jung-hyo Kim Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study Lupus Science and Medicine |
| title | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study |
| title_full | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study |
| title_fullStr | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study |
| title_full_unstemmed | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study |
| title_short | Mortality patterns of SLE and the associated risk factors in Korean patients: a nationwide cohort study |
| title_sort | mortality patterns of sle and the associated risk factors in korean patients a nationwide cohort study |
| url | https://lupus.bmj.com/content/12/1/e001361.full |
| work_keys_str_mv | AT sunyoungjung mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy AT yoonkyoungsung mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy AT sookyungcho mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy AT eunjinjang mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy AT yenajeon mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy AT junghyokim mortalitypatternsofsleandtheassociatedriskfactorsinkoreanpatientsanationwidecohortstudy |