Cumulative maternal lifetime stress & child asthma: effect modification by BMI
Background Investigations of maternal psychosocial stress and child asthma have produced mixed findings, which may reflect inconsistent consideration of modifying factors.Objective To examine associations between maternal lifetime stress and child asthma, and to assess effect modification by materna...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2024-12-01
|
| Series: | Stress |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10253890.2024.2435262 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138045415686144 |
|---|---|
| author | Nicole B. Ramsey Yueh-Hsiu Mathilda Chiu Hsiao-Hsien Leon Hsu Michelle Bosquet Enlow Brent A. Coull Rosalind J. Wright Kecia N. Carroll |
| author_facet | Nicole B. Ramsey Yueh-Hsiu Mathilda Chiu Hsiao-Hsien Leon Hsu Michelle Bosquet Enlow Brent A. Coull Rosalind J. Wright Kecia N. Carroll |
| author_sort | Nicole B. Ramsey |
| collection | DOAJ |
| description | Background Investigations of maternal psychosocial stress and child asthma have produced mixed findings, which may reflect inconsistent consideration of modifying factors.Objective To examine associations between maternal lifetime stress and child asthma, and to assess effect modification by maternal pre-pregnancy body mass index and race/ethnicity in a prenatal cohort of mother-child dyads.Methods Maternal lifetime stress was assessed using the Life Stressor Checklist-Revised, administered during pregnancy and child asthma was ascertained by parent-report in study follow-up visits. In the overall group and stratified by race/ethnicity, we used multivariable logistic regression and varying coefficient modeling to investigate the association between maternal stress and child asthma, assessing for effect modification by pre-pregnancy body mass index.Results Women were predominately Black (Black/Hispanic-Black 44.5%) or non-Black Hispanic (37.6%), with elevated pre-pregnancy body mass index (25.1% overweight, 29.8% obese); 17% of children had asthma. Higher maternal stress was associated with increased relative odds of child asthma only in dyads with women in the obese (≥30 kilograms/meters squared) category (odds ratio 1.84, 95% confidence interval 1.27-2.67). Varying coefficient models demonstrated stronger positive associations between increased maternal lifetime stress and child asthma in women with higher pre-pregnancy body mass index; the strongest association was observed in the Black group.Conclusion Maternal pre-pregnancy body mass index modified the association between maternal lifetime stress and child asthma. These findings underscore the need to consider complex interactions to fully elucidate intergenerational stress effects on early childhood asthma. |
| format | Article |
| id | doaj-art-42896e5eea834fb3bf0ad025696a5eae |
| institution | OA Journals |
| issn | 1025-3890 1607-8888 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Stress |
| spelling | doaj-art-42896e5eea834fb3bf0ad025696a5eae2025-08-20T02:30:39ZengTaylor & Francis GroupStress1025-38901607-88882024-12-0127110.1080/10253890.2024.2435262Cumulative maternal lifetime stress & child asthma: effect modification by BMINicole B. Ramsey0Yueh-Hsiu Mathilda Chiu1Hsiao-Hsien Leon Hsu2Michelle Bosquet Enlow3Brent A. Coull4Rosalind J. Wright5Kecia N. Carroll6The Kravis Children’s Hospital, Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Psychiatry and Behavioral Sciences, Boston Children’s Hospital and Department of Psychiatry, Harvard Medical School, Boston, MA, USADepartment of Biostatistics, Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USAThe Kravis Children’s Hospital, Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USAThe Kravis Children’s Hospital, Jack and Lucy Clark Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USABackground Investigations of maternal psychosocial stress and child asthma have produced mixed findings, which may reflect inconsistent consideration of modifying factors.Objective To examine associations between maternal lifetime stress and child asthma, and to assess effect modification by maternal pre-pregnancy body mass index and race/ethnicity in a prenatal cohort of mother-child dyads.Methods Maternal lifetime stress was assessed using the Life Stressor Checklist-Revised, administered during pregnancy and child asthma was ascertained by parent-report in study follow-up visits. In the overall group and stratified by race/ethnicity, we used multivariable logistic regression and varying coefficient modeling to investigate the association between maternal stress and child asthma, assessing for effect modification by pre-pregnancy body mass index.Results Women were predominately Black (Black/Hispanic-Black 44.5%) or non-Black Hispanic (37.6%), with elevated pre-pregnancy body mass index (25.1% overweight, 29.8% obese); 17% of children had asthma. Higher maternal stress was associated with increased relative odds of child asthma only in dyads with women in the obese (≥30 kilograms/meters squared) category (odds ratio 1.84, 95% confidence interval 1.27-2.67). Varying coefficient models demonstrated stronger positive associations between increased maternal lifetime stress and child asthma in women with higher pre-pregnancy body mass index; the strongest association was observed in the Black group.Conclusion Maternal pre-pregnancy body mass index modified the association between maternal lifetime stress and child asthma. These findings underscore the need to consider complex interactions to fully elucidate intergenerational stress effects on early childhood asthma.https://www.tandfonline.com/doi/10.1080/10253890.2024.2435262maternal lifetime psychosocial stressprenatalchildhood asthmabody mass indexrace/ethnicitypregnancy cohort |
| spellingShingle | Nicole B. Ramsey Yueh-Hsiu Mathilda Chiu Hsiao-Hsien Leon Hsu Michelle Bosquet Enlow Brent A. Coull Rosalind J. Wright Kecia N. Carroll Cumulative maternal lifetime stress & child asthma: effect modification by BMI Stress maternal lifetime psychosocial stress prenatal childhood asthma body mass index race/ethnicity pregnancy cohort |
| title | Cumulative maternal lifetime stress & child asthma: effect modification by BMI |
| title_full | Cumulative maternal lifetime stress & child asthma: effect modification by BMI |
| title_fullStr | Cumulative maternal lifetime stress & child asthma: effect modification by BMI |
| title_full_unstemmed | Cumulative maternal lifetime stress & child asthma: effect modification by BMI |
| title_short | Cumulative maternal lifetime stress & child asthma: effect modification by BMI |
| title_sort | cumulative maternal lifetime stress child asthma effect modification by bmi |
| topic | maternal lifetime psychosocial stress prenatal childhood asthma body mass index race/ethnicity pregnancy cohort |
| url | https://www.tandfonline.com/doi/10.1080/10253890.2024.2435262 |
| work_keys_str_mv | AT nicolebramsey cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT yuehhsiumathildachiu cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT hsiaohsienleonhsu cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT michellebosquetenlow cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT brentacoull cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT rosalindjwright cumulativematernallifetimestresschildasthmaeffectmodificationbybmi AT keciancarroll cumulativematernallifetimestresschildasthmaeffectmodificationbybmi |