Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model
Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, s...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/8310516 |
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| author | A. Schaschkow C. Mura S. Dal A. Langlois E. Seyfritz C. Sookhareea W. Bietiger C. Peronet N. Jeandidier M. Pinget S. Sigrist E. Maillard |
| author_facet | A. Schaschkow C. Mura S. Dal A. Langlois E. Seyfritz C. Sookhareea W. Bietiger C. Peronet N. Jeandidier M. Pinget S. Sigrist E. Maillard |
| author_sort | A. Schaschkow |
| collection | DOAJ |
| description | Exogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide better glycaemic control compared to injections in humans. The aim of this study was to compare the impacts of two modes of insulin administration (single injections of long-acting insulin or pump delivery of rapid-acting insulin) at the same dosage (4 IU/200 g/day) on rat metabolism and tissues. The rat weight and blood glucose levels were measured periodically after treatment. Immunostaining for signs of oxidative stress and for macrophages was performed on the liver and omental tissues. The continuous insulin delivery by pumps restored normoglycaemia, which induced the reduction of both reactive oxygen species and macrophage infiltration into the liver and omentum. Injections controlled the glucose levels for only a short period of time and therefore tissue stress and inflammation were elevated. In conclusion, the insulin administration mode has a crucial impact on rat metabolic parameters, which has to be taken into account when studies are designed. |
| format | Article |
| id | doaj-art-42893cd20e214a33bd5a5aecb0f59e49 |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-42893cd20e214a33bd5a5aecb0f59e492025-08-20T02:37:57ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/83105168310516Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat ModelA. Schaschkow0C. Mura1S. Dal2A. Langlois3E. Seyfritz4C. Sookhareea5W. Bietiger6C. Peronet7N. Jeandidier8M. Pinget9S. Sigrist10E. Maillard11UMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceUMR DIATHEC, EA 7294, Centre Européen d’Etude du Diabète, Université de Strasbourg (UdS), Boulevard René Leriche, 67200 Strasbourg, FranceExogenous insulin is the only treatment available for type 1 diabetic patients and is mostly administered by subcutaneous (SC) injection in a basal and bolus scheme using insulin pens (injection) or pumps (preimplanted SC catheter). Some divergence exists between these two modes of administration, since pumps provide better glycaemic control compared to injections in humans. The aim of this study was to compare the impacts of two modes of insulin administration (single injections of long-acting insulin or pump delivery of rapid-acting insulin) at the same dosage (4 IU/200 g/day) on rat metabolism and tissues. The rat weight and blood glucose levels were measured periodically after treatment. Immunostaining for signs of oxidative stress and for macrophages was performed on the liver and omental tissues. The continuous insulin delivery by pumps restored normoglycaemia, which induced the reduction of both reactive oxygen species and macrophage infiltration into the liver and omentum. Injections controlled the glucose levels for only a short period of time and therefore tissue stress and inflammation were elevated. In conclusion, the insulin administration mode has a crucial impact on rat metabolic parameters, which has to be taken into account when studies are designed.http://dx.doi.org/10.1155/2016/8310516 |
| spellingShingle | A. Schaschkow C. Mura S. Dal A. Langlois E. Seyfritz C. Sookhareea W. Bietiger C. Peronet N. Jeandidier M. Pinget S. Sigrist E. Maillard Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model Journal of Diabetes Research |
| title | Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model |
| title_full | Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model |
| title_fullStr | Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model |
| title_full_unstemmed | Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model |
| title_short | Impact of the Type of Continuous Insulin Administration on Metabolism in a Diabetic Rat Model |
| title_sort | impact of the type of continuous insulin administration on metabolism in a diabetic rat model |
| url | http://dx.doi.org/10.1155/2016/8310516 |
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