Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome
Background: Leptin and adiponectin, two members of the adipokine family, play roles in increasing lipid metabolism and inhibiting lipogenesis. Reduced levels of these cytokines are associated with obesity and insulin resistance. This study aimed to determine the serum levels of leptin and adiponecti...
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Golestan University of Medical Sciences
2024-11-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1853-en.pdf |
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| author | Sharabeh Hezarkhani Khosro Ghojoghi Sara Hosseinzadeh Naser Behnampour Farshid Fathabadi Zahra Hesari Hamid Reza Joshaghani |
| author_facet | Sharabeh Hezarkhani Khosro Ghojoghi Sara Hosseinzadeh Naser Behnampour Farshid Fathabadi Zahra Hesari Hamid Reza Joshaghani |
| author_sort | Sharabeh Hezarkhani |
| collection | DOAJ |
| description | Background: Leptin and adiponectin, two members of the adipokine family, play roles in increasing lipid metabolism and inhibiting lipogenesis. Reduced levels of these cytokines are associated with obesity and insulin resistance. This study aimed to determine the serum levels of leptin and adiponectin in type-2 diabetic patients with and without metabolic syndrome compared to a control group.
Methods: Three groups of individuals participated in this study: 47 type-2 diabetic patients with metabolic syndrome (DM+MetS), 25 type-2 diabetic patients without metabolic syndrome (DM-MetS), and 40 individuals with no history of diabetes or metabolic syndrome (Control group). Fasting blood samples were collected, and serum levels of fasting blood sugar, cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol were measured using the enzymatic method. Blood pressure, height, and weight were recorded using stadiometers, while leptin and adiponectin levels were determined via enzyme-linked immunosorbent assay.
Results: A significant difference was observed between the DM+MetS group and the DM-MetS group in serum leptin (p = 0.004) and adiponectin (p < 0.001) levels. In patients with type-2 diabetes and metabolic syndrome, serum leptin (p = 0.530) and adiponectin (p < 0.001) levels were lower compared to the control group.
Conclusion: A decrease in the serum levels of key adipokines, such as leptin and adiponectin, in type-2 diabetic patients may serve as a predictor of metabolic syndrome. |
| format | Article |
| id | doaj-art-42872238511c41d4a9cd8be3d88bc94d |
| institution | OA Journals |
| issn | 2538-4449 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj-art-42872238511c41d4a9cd8be3d88bc94d2025-08-20T02:19:23ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492024-11-011862831Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndromeSharabeh Hezarkhani0Khosro Ghojoghi1Sara Hosseinzadeh2Naser Behnampour3Farshid Fathabadi4Zahra Hesari5Hamid Reza Joshaghani6 Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Biostatistics Department, Faculty of Health, Golestan University of Medical Sciences, Gorgan, Iran Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Background: Leptin and adiponectin, two members of the adipokine family, play roles in increasing lipid metabolism and inhibiting lipogenesis. Reduced levels of these cytokines are associated with obesity and insulin resistance. This study aimed to determine the serum levels of leptin and adiponectin in type-2 diabetic patients with and without metabolic syndrome compared to a control group. Methods: Three groups of individuals participated in this study: 47 type-2 diabetic patients with metabolic syndrome (DM+MetS), 25 type-2 diabetic patients without metabolic syndrome (DM-MetS), and 40 individuals with no history of diabetes or metabolic syndrome (Control group). Fasting blood samples were collected, and serum levels of fasting blood sugar, cholesterol, triglycerides, HDL-cholesterol, and LDL-cholesterol were measured using the enzymatic method. Blood pressure, height, and weight were recorded using stadiometers, while leptin and adiponectin levels were determined via enzyme-linked immunosorbent assay. Results: A significant difference was observed between the DM+MetS group and the DM-MetS group in serum leptin (p = 0.004) and adiponectin (p < 0.001) levels. In patients with type-2 diabetes and metabolic syndrome, serum leptin (p = 0.530) and adiponectin (p < 0.001) levels were lower compared to the control group. Conclusion: A decrease in the serum levels of key adipokines, such as leptin and adiponectin, in type-2 diabetic patients may serve as a predictor of metabolic syndrome.http://mlj.goums.ac.ir/article-1-1853-en.pdfleptinadiponectindiabetes mellitusmetabolic syndrome |
| spellingShingle | Sharabeh Hezarkhani Khosro Ghojoghi Sara Hosseinzadeh Naser Behnampour Farshid Fathabadi Zahra Hesari Hamid Reza Joshaghani Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome Medical Laboratory Journal leptin adiponectin diabetes mellitus metabolic syndrome |
| title | Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome |
| title_full | Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome |
| title_fullStr | Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome |
| title_full_unstemmed | Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome |
| title_short | Evaluation of serum adiponectin and leptin levels in type 2 diabetic patients: The potential role in predicting metabolic syndrome |
| title_sort | evaluation of serum adiponectin and leptin levels in type 2 diabetic patients the potential role in predicting metabolic syndrome |
| topic | leptin adiponectin diabetes mellitus metabolic syndrome |
| url | http://mlj.goums.ac.ir/article-1-1853-en.pdf |
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