Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis
Researchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have gar...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495810/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558685405413376 |
|---|---|
| author | Yun Rong Xu Dai Yuan Tang Zhen Ping Xiao Zai Tian Huang Heng Rui Zhang Zi Wen Tang Fei He |
| author_facet | Yun Rong Xu Dai Yuan Tang Zhen Ping Xiao Zai Tian Huang Heng Rui Zhang Zi Wen Tang Fei He |
| author_sort | Yun Rong Xu |
| collection | DOAJ |
| description | Researchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have garnered increasing attention. In vitro, the orientation and diameter of scaffold materials can exert different effects on osteogenesis and vascularisation. However, more comprehensive investigations, including in vivo studies, are required to confirm the results observed in vitro. Accordingly, in the present study, fibre scaffolds with various orientations and diameters were prepared by electrospinning with polylactic acid. The effects of the micromorphological characteristics of these scaffolds with different orientations and diameters on osteogenesis and vascularisation were systematically studied via in vivo experiments. The scaffolds with aligned micromorphological features positively affected osteogenesis and vascularisation, which indicated that such characteristics could be considered crucial factors when designing materials for bone repair. |
| format | Article |
| id | doaj-art-4281747ad3ec4d7a9fb22fc657243897 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-4281747ad3ec4d7a9fb22fc6572438972025-01-06T06:59:38ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-01-011210.3389/fbioe.2024.14958101495810Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesisYun Rong Xu0Dai Yuan Tang1Zhen Ping Xiao2Zai Tian Huang3Heng Rui Zhang4Zi Wen Tang5Fei He6Qujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaQujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaQujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaQujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaQujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaThe First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaQujing Affiliated Hospital of Kunming Medical University, Qujing, ChinaResearchers in the field of regenerative medicine have consistently focused on the biomimetic design of engineered bone materials on the basis of the microstructure of natural bone tissue. Additionally, the effects of the micromorphological characteristics of these materials on angiogenesis have garnered increasing attention. In vitro, the orientation and diameter of scaffold materials can exert different effects on osteogenesis and vascularisation. However, more comprehensive investigations, including in vivo studies, are required to confirm the results observed in vitro. Accordingly, in the present study, fibre scaffolds with various orientations and diameters were prepared by electrospinning with polylactic acid. The effects of the micromorphological characteristics of these scaffolds with different orientations and diameters on osteogenesis and vascularisation were systematically studied via in vivo experiments. The scaffolds with aligned micromorphological features positively affected osteogenesis and vascularisation, which indicated that such characteristics could be considered crucial factors when designing materials for bone repair.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495810/fullmicromorphologypolylactic acidorientationdiameterosteogenesisvascular generation |
| spellingShingle | Yun Rong Xu Dai Yuan Tang Zhen Ping Xiao Zai Tian Huang Heng Rui Zhang Zi Wen Tang Fei He Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis Frontiers in Bioengineering and Biotechnology micromorphology polylactic acid orientation diameter osteogenesis vascular generation |
| title | Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| title_full | Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| title_fullStr | Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| title_full_unstemmed | Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| title_short | Effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| title_sort | effects of polylactic acid scaffolds with various orientations and diameters on osteogenesis and angiogenesis |
| topic | micromorphology polylactic acid orientation diameter osteogenesis vascular generation |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1495810/full |
| work_keys_str_mv | AT yunrongxu effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT daiyuantang effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT zhenpingxiao effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT zaitianhuang effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT hengruizhang effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT ziwentang effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis AT feihe effectsofpolylacticacidscaffoldswithvariousorientationsanddiametersonosteogenesisandangiogenesis |