Optochemical control of G1 cell cycle by regulating CDK4/6 degradation

Optochemical control of G1 cell cycle by regulating CDK4/6 degradation

Summary: Cancer progression is characterized by dysregulated G1/S phase transition mediated by CDK4/6-dependent Rb protein phosphorylation. Although CDK4/6 degraders show encouraging anti-tumor efficacy, it is highly desired to develop strategies to spatiotemporally control the release of active CDK...

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Bibliographic Details
Main Authors: Tianyi Wang, Yaming Zhang, Yuwei Liu, Lichao Wang, Lijun Liu, Weiping Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225015652
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