Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab
Background: Recurrent pregnancy loss (RPL) is defined as the failure of two or more clinically recognised pregnancies before 20 weeks of gestation. The prevalence of clinically evident RPL is 1%–2% worldwide. The aetiologies of RPL include uterine anatomic anomalies, uncontrolled diabetes mellitus,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
|
| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jhrs.jhrs_24_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860950691741696 |
|---|---|
| author | Amanjot Kaur Rayat Pallvi Thapar Mandeep Kaur Sukhjashanpreet Singh Anupam Kaur |
| author_facet | Amanjot Kaur Rayat Pallvi Thapar Mandeep Kaur Sukhjashanpreet Singh Anupam Kaur |
| author_sort | Amanjot Kaur Rayat |
| collection | DOAJ |
| description | Background:
Recurrent pregnancy loss (RPL) is defined as the failure of two or more clinically recognised pregnancies before 20 weeks of gestation. The prevalence of clinically evident RPL is 1%–2% worldwide. The aetiologies of RPL include uterine anatomic anomalies, uncontrolled diabetes mellitus, untreated hypothyroidism, parental chromosomal abnormalities, antiphospholipid antibody syndrome, thrombophilia, genetic abnormalities and infections.
Aims:
This study was aimed at investigating the possible association between CYP11A1 (rs11632698) and (rs4077582) polymorphisms with RPL in the female population of Punjab.
Settings and Design:
The case– control study was conducted on 170 subjects, of which 80 RPL cases and 90 controls were analysed.
Materials and Methods:
Genotypic analysis was performed using the polymerase chain reaction – restriction fragment length polymorphism. Statistical Analysis Used: Pearson’s Chi-square test was used.
Results:
The genotypic frequency of CYP11A1 (rs11632698) A > G polymorphism was statistically significantly different amongst cases and controls (P = 0.00001). It was observed that the presence of the G allele might increase the risk of RPL. A Chisquare analysis of CYP11A1 (rs4077582) (P = 0.01) indicated a significant difference amongst the genotypes of cases and controls of RPL.
Conclusion:
CYP11A1 variants (rs11632698 and rs4077582) may be useful markers in determining the genetic susceptibility to the pathogenesis of RPL. Keywords: CYP11A1, recurrent miscarriage, recurrent pregnancy loss, rs11632698, rs4077582, spontaneous abortion. |
| format | Article |
| id | doaj-art-427d30db31654788a7138d2b5fbcc73d |
| institution | Kabale University |
| issn | 0974-1208 1998-4766 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj-art-427d30db31654788a7138d2b5fbcc73d2025-02-10T07:46:44ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662023-07-0116324224510.4103/jhrs.jhrs_24_23Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of PunjabAmanjot Kaur RayatPallvi ThaparMandeep KaurSukhjashanpreet SinghAnupam KaurBackground: Recurrent pregnancy loss (RPL) is defined as the failure of two or more clinically recognised pregnancies before 20 weeks of gestation. The prevalence of clinically evident RPL is 1%–2% worldwide. The aetiologies of RPL include uterine anatomic anomalies, uncontrolled diabetes mellitus, untreated hypothyroidism, parental chromosomal abnormalities, antiphospholipid antibody syndrome, thrombophilia, genetic abnormalities and infections. Aims: This study was aimed at investigating the possible association between CYP11A1 (rs11632698) and (rs4077582) polymorphisms with RPL in the female population of Punjab. Settings and Design: The case– control study was conducted on 170 subjects, of which 80 RPL cases and 90 controls were analysed. Materials and Methods: Genotypic analysis was performed using the polymerase chain reaction – restriction fragment length polymorphism. Statistical Analysis Used: Pearson’s Chi-square test was used. Results: The genotypic frequency of CYP11A1 (rs11632698) A > G polymorphism was statistically significantly different amongst cases and controls (P = 0.00001). It was observed that the presence of the G allele might increase the risk of RPL. A Chisquare analysis of CYP11A1 (rs4077582) (P = 0.01) indicated a significant difference amongst the genotypes of cases and controls of RPL. Conclusion: CYP11A1 variants (rs11632698 and rs4077582) may be useful markers in determining the genetic susceptibility to the pathogenesis of RPL. Keywords: CYP11A1, recurrent miscarriage, recurrent pregnancy loss, rs11632698, rs4077582, spontaneous abortion.https://journals.lww.com/10.4103/jhrs.jhrs_24_23cyp11a1recurrent miscarriagerecurrent pregnancy lossrs11632698rs4077582spontaneous abortion |
| spellingShingle | Amanjot Kaur Rayat Pallvi Thapar Mandeep Kaur Sukhjashanpreet Singh Anupam Kaur Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab Journal of Human Reproductive Sciences cyp11a1 recurrent miscarriage recurrent pregnancy loss rs11632698 rs4077582 spontaneous abortion |
| title | Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab |
| title_full | Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab |
| title_fullStr | Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab |
| title_full_unstemmed | Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab |
| title_short | Association of CYP11A1 Polymorphisms with Recurrent Pregnancy Loss in the Female Population of Punjab |
| title_sort | association of cyp11a1 polymorphisms with recurrent pregnancy loss in the female population of punjab |
| topic | cyp11a1 recurrent miscarriage recurrent pregnancy loss rs11632698 rs4077582 spontaneous abortion |
| url | https://journals.lww.com/10.4103/jhrs.jhrs_24_23 |
| work_keys_str_mv | AT amanjotkaurrayat associationofcyp11a1polymorphismswithrecurrentpregnancylossinthefemalepopulationofpunjab AT pallvithapar associationofcyp11a1polymorphismswithrecurrentpregnancylossinthefemalepopulationofpunjab AT mandeepkaur associationofcyp11a1polymorphismswithrecurrentpregnancylossinthefemalepopulationofpunjab AT sukhjashanpreetsingh associationofcyp11a1polymorphismswithrecurrentpregnancylossinthefemalepopulationofpunjab AT anupamkaur associationofcyp11a1polymorphismswithrecurrentpregnancylossinthefemalepopulationofpunjab |