Interstitial Granulomatous Drug Reaction to Ustekinumab

Interstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE...

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Main Authors: A. Walker, J. S. Westerdahl, J. Zussman, J. Mathis
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Case Reports in Dermatological Medicine
Online Access:http://dx.doi.org/10.1155/2022/1461145
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author A. Walker
J. S. Westerdahl
J. Zussman
J. Mathis
author_facet A. Walker
J. S. Westerdahl
J. Zussman
J. Mathis
author_sort A. Walker
collection DOAJ
description Interstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE inhibitors, antihistamines, beta-blockers, antidepressants, and anticonvulsants. Ustekinumab is a human monoclonal antibody that targets inflammatory cytokines IL-12 and IL-23 and has been have shown to be effective in treating IGDR. However, we present a case that suggests ustekinumab can also act as an inciting agent for IGDR.
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institution Kabale University
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publisher Wiley
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series Case Reports in Dermatological Medicine
spelling doaj-art-427acb34ef29479589bd2a86dd831bea2025-02-03T06:05:54ZengWileyCase Reports in Dermatological Medicine2090-64712022-01-01202210.1155/2022/1461145Interstitial Granulomatous Drug Reaction to UstekinumabA. Walker0J. S. Westerdahl1J. Zussman2J. Mathis3University of Utah School of MedicineUniversity of Utah School of MedicineUniversity of UtahUniversity of UtahInterstitial granulomatous drug reaction (IGDR) is a distinct inflammatory process that often presents as annular, violaceous plaques distributed on the extremities, proximal trunk, and intertriginous areas. The list of drugs implicated for inciting IGDR is growing, but most prominently includes ACE inhibitors, antihistamines, beta-blockers, antidepressants, and anticonvulsants. Ustekinumab is a human monoclonal antibody that targets inflammatory cytokines IL-12 and IL-23 and has been have shown to be effective in treating IGDR. However, we present a case that suggests ustekinumab can also act as an inciting agent for IGDR.http://dx.doi.org/10.1155/2022/1461145
spellingShingle A. Walker
J. S. Westerdahl
J. Zussman
J. Mathis
Interstitial Granulomatous Drug Reaction to Ustekinumab
Case Reports in Dermatological Medicine
title Interstitial Granulomatous Drug Reaction to Ustekinumab
title_full Interstitial Granulomatous Drug Reaction to Ustekinumab
title_fullStr Interstitial Granulomatous Drug Reaction to Ustekinumab
title_full_unstemmed Interstitial Granulomatous Drug Reaction to Ustekinumab
title_short Interstitial Granulomatous Drug Reaction to Ustekinumab
title_sort interstitial granulomatous drug reaction to ustekinumab
url http://dx.doi.org/10.1155/2022/1461145
work_keys_str_mv AT awalker interstitialgranulomatousdrugreactiontoustekinumab
AT jswesterdahl interstitialgranulomatousdrugreactiontoustekinumab
AT jzussman interstitialgranulomatousdrugreactiontoustekinumab
AT jmathis interstitialgranulomatousdrugreactiontoustekinumab