National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023»
Objective. To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) in various regions of Russia in 2023. Materials and Methods. The study included 1098 isolates obtained from the urine of children and a...
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Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy
2024-09-01
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| Series: | Клиническая микробиология и антимикробная химиотерапия |
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| Online Access: | https://cmac-journal.ru/publication/2024/3/cmac-2024-t26-n3-p328/cmac-2024-t26-n3-p328.pdf |
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| author | Kozlov R.S. Palagin I.S. Ivanchik N.V. Trushin I.V. Dekhnich A.V. Edelstein M.V. Perepanova T.S. Belashova M.A. Nastausheva T.L. Ivanova I.A. Valiullina I.R. Momotova A.A. Shirokova T.M. Kotov S.V. Pul'bere S.A. Petrova L.V. Eremeeva A.V. Popov S.V. Zhukov V.A. Suhorukova M.V. Plugin P.S. Nikitina I.V. Vityazeva V.P. Zlobnaya K.A. Ibishev H.S. Naboka Yu.L. Kuz'min I.V. Petrov S.B. Slesarevskaya M.N. Savicheva A.M. Husnutdinova T.A. Moskvitina E.N. Andronova T.I. Dolzhenko E.V. Sholomova L.A. Burasova E.G. Lupyreva E.G. Malyavin A.I. Sidorova R.K. Mihajlichenko A.O. Kataeva E.I. Shamaeva S.H. Ahremenko Ya.A. Portnyagina U.S. Ershova M.G. |
| author_facet | Kozlov R.S. Palagin I.S. Ivanchik N.V. Trushin I.V. Dekhnich A.V. Edelstein M.V. Perepanova T.S. Belashova M.A. Nastausheva T.L. Ivanova I.A. Valiullina I.R. Momotova A.A. Shirokova T.M. Kotov S.V. Pul'bere S.A. Petrova L.V. Eremeeva A.V. Popov S.V. Zhukov V.A. Suhorukova M.V. Plugin P.S. Nikitina I.V. Vityazeva V.P. Zlobnaya K.A. Ibishev H.S. Naboka Yu.L. Kuz'min I.V. Petrov S.B. Slesarevskaya M.N. Savicheva A.M. Husnutdinova T.A. Moskvitina E.N. Andronova T.I. Dolzhenko E.V. Sholomova L.A. Burasova E.G. Lupyreva E.G. Malyavin A.I. Sidorova R.K. Mihajlichenko A.O. Kataeva E.I. Shamaeva S.H. Ahremenko Ya.A. Portnyagina U.S. Ershova M.G. |
| author_sort | Kozlov R.S. |
| collection | DOAJ |
| description | Objective.
To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) in various regions of Russia in 2023.
Materials and Methods.
The study included 1098 isolates obtained from the urine of children and adults of both sexes of all age groups with acute and exacerbation of recurrent community-acquired UTIs, including pregnant women with asymptomatic bacteriuria. Isolates were collected in 29 centers in 21 cities of Russia in 2023 as part of a multicenter prospective epidemiological study of the dynamics of antibiotic resistance of pathogens causing community-acquired UTIs in different subsets of patients ("DARMIS-2023"). The categories of susceptibility of isolates to antimicrobial drugs were based on the breakpoint values of minimum inhibitory concentrations (MIC) in accordance with the Russian recommendations "Determination of susceptibility of microorganisms to antimicrobial drugs" (Version 2024-02) and the updated EUCAST criteria (v. 14.0, 2024).
Results.
Enterobacterales accounted for a total of 88.1% of all isolated bacterial pathogens (89.6% in the adult subpopulation; 82.8% in the pregnant subpopulation and 89.6% in the subpopulation of children and adolescents under 18 years of age). The most prevalent species were Escherichia coli (72.2% in the adult subpopulation; 72.8% in the pregnant women subpopulation and 68.9% in the children and adolescents under 18 years of age subpopulation) and Klebsiella pneumoniae (10.8% in the adult subpopulation; 4.8% in the pregnant women subpopulation and 9.8% in the children and adolescents under 18 years of age subpopulation). Of the oral drugs, the minimal resistance in E. coli was demonstrated for nitrofurantoin (0.4% of isolates in the adult subpopulation; 0.0% in the pregnant women subpopulation and 1.6% in the children and adolescents under 18 years of age subpopulation) and fosfomycin (9.6% of isolates in the adult subpopulation; 4.4% in the pregnant women subpopulation and 1.6% in the children and adolescents under 18 years of age subpopulation). Of the parenteral agents, meropenem and amikacin had the highest activity: 0.8% and 1.0% resistant E. coli in the adult subpopulation; no resistant E. coli in the pregnant subpopulation; 0.0% and 0.8% in the children and adolescents under 18 years of age subpopulation, respectively. For each patient subpopulation, antimicrobial resistance of E. coli to ampicillin, amoxicillin/clavulanic acid, cefotaxime, cefixime, and trimethoprim-sulfamethoxazole was more than 20%. Rates of E. coli resistance to ciprofloxacin were 36.7% in the adult subpopulation; 22.1% in the pregnant subpopulation; and 22.2% in the children and adolescents under 18 years of age subpopulation. The rate of extended-spectrum beta-lactamase production based on phenotypic test results was 29.6% in the adult subpopulation; 23.6% in the pregnant subpopulation and 33.3% in the children and adolescents under 18 years of age subpopulation.
Conclusions.
In community-acquired UTIs the main clinical problem is the persistent high rate of E. coli resistance to cephalosporins, fluoroquinolones, aminopenicillins/beta-lactamase inhibitors, as well as the increase of the extended-spectrum beta-lactamases production. Remaining high in vitro activity of fosfomycin and nitrofurans allows to consider them as drugs of choice in uncomplicated lower urinary tract infections. |
| format | Article |
| id | doaj-art-4279ba55c6e1433483daa7b0c3b550d4 |
| institution | Kabale University |
| issn | 1684-4386 2686-9586 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy |
| record_format | Article |
| series | Клиническая микробиология и антимикробная химиотерапия |
| spelling | doaj-art-4279ba55c6e1433483daa7b0c3b550d42025-01-14T06:34:51ZrusInterregional Association for Clinical Microbiology and Antimicrobial ChemotherapyКлиническая микробиология и антимикробная химиотерапия1684-43862686-95862024-09-0126332833710.36488/cmac.2024.3.328-337cmac-2024-t26-n3-p328National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023»Kozlov R.S.0Palagin I.S.1Ivanchik N.V.2Trushin I.V.3Dekhnich A.V.4Edelstein M.V.5Perepanova T.S.6Belashova M.A.7Nastausheva T.L.8Ivanova I.A.9Valiullina I.R.10Momotova A.A.11Shirokova T.M.12Kotov S.V.13Pul'bere S.A.14Petrova L.V.15Eremeeva A.V.16Popov S.V.17Zhukov V.A.18Suhorukova M.V.19Plugin P.S.20Nikitina I.V.21Vityazeva V.P.22Zlobnaya K.A.23Ibishev H.S.24Naboka Yu.L.25Kuz'min I.V.26Petrov S.B.27Slesarevskaya M.N.28Savicheva A.M.29Husnutdinova T.A.30Moskvitina E.N.31Andronova T.I.32Dolzhenko E.V.33Sholomova L.A.34Burasova E.G.35Lupyreva E.G.36Malyavin A.I.37Sidorova R.K.38Mihajlichenko A.O.39Kataeva E.I.40Shamaeva S.H.41Ahremenko Ya.A.42Portnyagina U.S.43Ershova M.G.44Smolensk State Medical University, Smolensk, RussiaSmolensk State Medical University, Smolensk, RussiaSmolensk State Medical University, Smolensk, RussiaSmolensk State Medical University, Smolensk, RussiaSmolensk State Medical University, Smolensk, RussiaSmolensk State Medical University, Smolensk, RussiaInstitute of Urology and Interventional Radiology named after N.A. Lopatkin, Moscow, RussiaOGBUZ «BOKB Svyatitelya Ioasafa», BelgorodFGBOU VO «VGMU im. N.N. Burdenko» Minzdrava Rossii, VoronezhGBU «RME RCPB SPID i IZ», Joshkar-OlaGAUZ «RKB MZ RT», Kazan'KOGBUZ «KOKPC», KirovKOGBUZ «KOKPC», KirovFGAOU VO «RNIMU im. N.I. Pirogova» Minzdrava Rossii, MoskvaFGAOU VO «RNIMU im. N.I. Pirogova» Minzdrava Rossii, MoskvaFGBU «NMHC im. N.I. Pirogova», MoskvaFGAOU VO «Pervyj MGMU im. I.M. Sechenova» Minzdrava Rossii, MoskvaFGAOU VO «Rossijskij universitet druzhby narodov im. P. Lumumby»FGAOU VO «Rossijskij universitet druzhby narodov im. P. Lumumby»FGAU «NMIC nejrohirurgii im. ak. N.N. Burdenko» Minzdrava Rossii, MoskvaGBUZ NO «GKBSMP№2», NovosibirskGBUZ NSO «DGKB №4 im. V.S. Geras'kova», NovosibirskGBUZ «DRB im. I.N. Grigovicha», PetrozavodskGBUZ «DRB im. I.N. Grigovicha», PetrozavodskFGBOU VO «RostGMU» Minzdrava Rossii, Rostov-na-DonuFGBOU VO «RostGMU» Minzdrava Rossii, Rostov-na-DonuFGBOU VO «PSPbGMU im. akad. I.P. Pavlova» Minzdrava Rossii, Sankt-PeterburgNIC urologii PSPbGMU im. I.P. Pavlova Minzdrava Rossii, Sankt-PeterburgNIC urologii PSPbGMU im. I.P. Pavlova Minzdrava Rossii, Sankt-PeterburgFGBNU «NII AGiR im. D.O. Otta», Sankt-PeterburgFGBNU «NII AGiR im. D.O. Otta», Sankt-PeterburgFGBU SibFNKC FMBA Rossii, SeverskGBUZ RK «SGKB №7», Simferopol'GBUZ «CSVMP im. V.P. Avaeva», Tver'GBUZ SO «TGKB№5», Tol'yattiGAUZ «RKB im. N.A. Semashko» Minzdrava RB, Ulan-UdeGBUZ «RKIB», Ulan-UdeGUZ «GP№4», Ul'yanovskGUZ «GP№4», Ul'yanovskKGBUZ «KKB im. prof. S.I. Sergeeva» Minzdrava HKFGBOU VO «ChelGU», ChelyabinskGBU RSYa «RB№2-CEMP», YakutskFGAOU VO «SVFU im. M.K. Ammosova», YakutskFGAOU VO «SVFU im. M.K. Ammosova», YakutskGBUZ YaO «OIKB», Yaroslavl'Objective. To study in vitro activity of antimicrobials against clinical isolates obtained from patients with community-acquired urinary tract infections (UTIs) in various regions of Russia in 2023. Materials and Methods. The study included 1098 isolates obtained from the urine of children and adults of both sexes of all age groups with acute and exacerbation of recurrent community-acquired UTIs, including pregnant women with asymptomatic bacteriuria. Isolates were collected in 29 centers in 21 cities of Russia in 2023 as part of a multicenter prospective epidemiological study of the dynamics of antibiotic resistance of pathogens causing community-acquired UTIs in different subsets of patients ("DARMIS-2023"). The categories of susceptibility of isolates to antimicrobial drugs were based on the breakpoint values of minimum inhibitory concentrations (MIC) in accordance with the Russian recommendations "Determination of susceptibility of microorganisms to antimicrobial drugs" (Version 2024-02) and the updated EUCAST criteria (v. 14.0, 2024). Results. Enterobacterales accounted for a total of 88.1% of all isolated bacterial pathogens (89.6% in the adult subpopulation; 82.8% in the pregnant subpopulation and 89.6% in the subpopulation of children and adolescents under 18 years of age). The most prevalent species were Escherichia coli (72.2% in the adult subpopulation; 72.8% in the pregnant women subpopulation and 68.9% in the children and adolescents under 18 years of age subpopulation) and Klebsiella pneumoniae (10.8% in the adult subpopulation; 4.8% in the pregnant women subpopulation and 9.8% in the children and adolescents under 18 years of age subpopulation). Of the oral drugs, the minimal resistance in E. coli was demonstrated for nitrofurantoin (0.4% of isolates in the adult subpopulation; 0.0% in the pregnant women subpopulation and 1.6% in the children and adolescents under 18 years of age subpopulation) and fosfomycin (9.6% of isolates in the adult subpopulation; 4.4% in the pregnant women subpopulation and 1.6% in the children and adolescents under 18 years of age subpopulation). Of the parenteral agents, meropenem and amikacin had the highest activity: 0.8% and 1.0% resistant E. coli in the adult subpopulation; no resistant E. coli in the pregnant subpopulation; 0.0% and 0.8% in the children and adolescents under 18 years of age subpopulation, respectively. For each patient subpopulation, antimicrobial resistance of E. coli to ampicillin, amoxicillin/clavulanic acid, cefotaxime, cefixime, and trimethoprim-sulfamethoxazole was more than 20%. Rates of E. coli resistance to ciprofloxacin were 36.7% in the adult subpopulation; 22.1% in the pregnant subpopulation; and 22.2% in the children and adolescents under 18 years of age subpopulation. The rate of extended-spectrum beta-lactamase production based on phenotypic test results was 29.6% in the adult subpopulation; 23.6% in the pregnant subpopulation and 33.3% in the children and adolescents under 18 years of age subpopulation. Conclusions. In community-acquired UTIs the main clinical problem is the persistent high rate of E. coli resistance to cephalosporins, fluoroquinolones, aminopenicillins/beta-lactamase inhibitors, as well as the increase of the extended-spectrum beta-lactamases production. Remaining high in vitro activity of fosfomycin and nitrofurans allows to consider them as drugs of choice in uncomplicated lower urinary tract infections.https://cmac-journal.ru/publication/2024/3/cmac-2024-t26-n3-p328/cmac-2024-t26-n3-p328.pdfcommunityacquired infectionsurinary tract infectionscystitispyelonephritisenterobacteralesescherichia coliantimicrobial resistanceciprofloxacinfosfomycinnitrofurantoin |
| spellingShingle | Kozlov R.S. Palagin I.S. Ivanchik N.V. Trushin I.V. Dekhnich A.V. Edelstein M.V. Perepanova T.S. Belashova M.A. Nastausheva T.L. Ivanova I.A. Valiullina I.R. Momotova A.A. Shirokova T.M. Kotov S.V. Pul'bere S.A. Petrova L.V. Eremeeva A.V. Popov S.V. Zhukov V.A. Suhorukova M.V. Plugin P.S. Nikitina I.V. Vityazeva V.P. Zlobnaya K.A. Ibishev H.S. Naboka Yu.L. Kuz'min I.V. Petrov S.B. Slesarevskaya M.N. Savicheva A.M. Husnutdinova T.A. Moskvitina E.N. Andronova T.I. Dolzhenko E.V. Sholomova L.A. Burasova E.G. Lupyreva E.G. Malyavin A.I. Sidorova R.K. Mihajlichenko A.O. Kataeva E.I. Shamaeva S.H. Ahremenko Ya.A. Portnyagina U.S. Ershova M.G. National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» Клиническая микробиология и антимикробная химиотерапия communityacquired infections urinary tract infections cystitis pyelonephritis enterobacterales escherichia coli antimicrobial resistance ciprofloxacin fosfomycin nitrofurantoin |
| title | National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» |
| title_full | National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» |
| title_fullStr | National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» |
| title_full_unstemmed | National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» |
| title_short | National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study «DARMIS -2023» |
| title_sort | national monitoring of antibiotic resistance of pathogens causing community acquired urinary tract infections in russia results of the multicenter epidemiological study darmis 2023 |
| topic | communityacquired infections urinary tract infections cystitis pyelonephritis enterobacterales escherichia coli antimicrobial resistance ciprofloxacin fosfomycin nitrofurantoin |
| url | https://cmac-journal.ru/publication/2024/3/cmac-2024-t26-n3-p328/cmac-2024-t26-n3-p328.pdf |
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