Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons

Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons

Abstract R2 elements, a class of non-long terminal repeat (non-LTR) retrotransposons, have the potential to be harnessed for transgene insertion. However, efforts to achieve this are limited by our understanding of the retrotransposon mechanisms. Here, we structurally and biochemically characterize...

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Main Authors: KeHuan K. Edmonds, Max E. Wilkinson, Daniel Strebinger, Hongyu Chen, Blake Lash, Clarissa C. Schaefer, Shiyou Zhu, Dangliang Liu, Shai Zilberzwige-Tal, Alim Ladha, Michelle L. Walsh, Chris J. Frangieh, Nicholas A. Vaz Reay, Rhiannon K. Macrae, Xiao Wang, Feng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61321-z
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