Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review
Acute lymphoblastic leukemia (ALL) represents only 20 % of adult acute leukemias, while Lymphoblastic lymphoma is even rarer, accounting for 2 % of adult non-Hodgkin lymphomas. T-acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms characterized by the presence of...
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Elsevier
2025-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213048925000081 |
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| author | Alaa Eldein Yahia Ibrahim Motabi Abdullah A. Alsakkaf Kamal Alzahrani Laila M. Alsuhaibani Bilal Albtoosh Abdullah Khaled AlBathi Abdullah M. Alrajhi |
| author_facet | Alaa Eldein Yahia Ibrahim Motabi Abdullah A. Alsakkaf Kamal Alzahrani Laila M. Alsuhaibani Bilal Albtoosh Abdullah Khaled AlBathi Abdullah M. Alrajhi |
| author_sort | Alaa Eldein Yahia |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) represents only 20 % of adult acute leukemias, while Lymphoblastic lymphoma is even rarer, accounting for 2 % of adult non-Hodgkin lymphomas. T-acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms characterized by the presence of immature T-cell precursors or lymphoblasts. Relapsed T-ALL or LBL is associated with a very poor prognosis, necessitating the exploration of novel therapeutic approaches. This case report describes the use of Venetoclax in combination with Cladribine, Idarubicin, and Cytarabine (CLIA) as salvage therapy for relapsed T-ALL/T-LBL. The treatment regimen resulted in remission and negative minimal residual disease. However, it was accompanied by delayed count recovery, febrile neutropenia, and Central Line-Associated Bloodstream Infection. The management of central nervous system involvement was challenging due to low platelet counts requiring transfusion support. The findings highlight the need for further investigation into the efficacy and optimal therapeutic regimen for relapsed T-ALL/T-LBL. Additionally, the case emphasizes the importance of early salvage therapy and potentially consolidative hematopoietic stem cell transplantation for improved survival outcomes in relapsed T-ALL/T-LBL patients. |
| format | Article |
| id | doaj-art-42739a2a67e045a185948e16378b8512 |
| institution | Kabale University |
| issn | 2213-0489 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-42739a2a67e045a185948e16378b85122025-08-20T03:30:47ZengElsevierLeukemia Research Reports2213-04892025-01-012310050610.1016/j.lrr.2025.100506Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature reviewAlaa Eldein Yahia0Ibrahim Motabi1Abdullah A. Alsakkaf2Kamal Alzahrani3Laila M. Alsuhaibani4Bilal Albtoosh5Abdullah Khaled AlBathi6Abdullah M. Alrajhi7Department of Adult Hematology, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Adult Hematology, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Adult Hematology, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Adult Hematology, King Fahad Medical City, Riyadh, Saudi ArabiaHematopathology Department, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Nursing, King Fahad Medical City, Riyadh, Saudi ArabiaDepartment of Radiology, King Fahad Medical City, Riyadh, Saudi ArabiaClinical Pharmacy Department, King Fahad Medical City, Riyadh, Saudi Arabia; Department of Pharmacy Practice, College of Pharmacy, AlFaisal University, Riyadh, Saudi Arabia; Corresponding author at: Clinical Pharmacy Department, King Fahad Medical City, Prince Abdulaziz Ibn Musaid S, FC4.2016, Riyadh, RH 12231, Saudi Arabia.Acute lymphoblastic leukemia (ALL) represents only 20 % of adult acute leukemias, while Lymphoblastic lymphoma is even rarer, accounting for 2 % of adult non-Hodgkin lymphomas. T-acute lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) are neoplasms characterized by the presence of immature T-cell precursors or lymphoblasts. Relapsed T-ALL or LBL is associated with a very poor prognosis, necessitating the exploration of novel therapeutic approaches. This case report describes the use of Venetoclax in combination with Cladribine, Idarubicin, and Cytarabine (CLIA) as salvage therapy for relapsed T-ALL/T-LBL. The treatment regimen resulted in remission and negative minimal residual disease. However, it was accompanied by delayed count recovery, febrile neutropenia, and Central Line-Associated Bloodstream Infection. The management of central nervous system involvement was challenging due to low platelet counts requiring transfusion support. The findings highlight the need for further investigation into the efficacy and optimal therapeutic regimen for relapsed T-ALL/T-LBL. Additionally, the case emphasizes the importance of early salvage therapy and potentially consolidative hematopoietic stem cell transplantation for improved survival outcomes in relapsed T-ALL/T-LBL patients.http://www.sciencedirect.com/science/article/pii/S2213048925000081VenetoclaxCladribineIdarubicinCytarabineT-cell acute lymphoblastic lymphoma |
| spellingShingle | Alaa Eldein Yahia Ibrahim Motabi Abdullah A. Alsakkaf Kamal Alzahrani Laila M. Alsuhaibani Bilal Albtoosh Abdullah Khaled AlBathi Abdullah M. Alrajhi Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review Leukemia Research Reports Venetoclax Cladribine Idarubicin Cytarabine T-cell acute lymphoblastic lymphoma |
| title | Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review |
| title_full | Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review |
| title_fullStr | Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review |
| title_full_unstemmed | Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review |
| title_short | Venetoclax combination with Cladribine, idarubicin, Cytarabine for relapsed T-Cell acute lymphoblastic leukemia/lymphoblastic lymphoma treatment: A case report and literature review |
| title_sort | venetoclax combination with cladribine idarubicin cytarabine for relapsed t cell acute lymphoblastic leukemia lymphoblastic lymphoma treatment a case report and literature review |
| topic | Venetoclax Cladribine Idarubicin Cytarabine T-cell acute lymphoblastic lymphoma |
| url | http://www.sciencedirect.com/science/article/pii/S2213048925000081 |
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