Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization

Evodiamine inhibits colorectal cancer cell stemness by disturbing ubiquitin specific protease 4 mediated SOX9 stabilization

Abstract Colorectal cancer (CRC) is the third most common cancer and the second most deadly cancer worldwide. It is of great importance to explore new mechanisms and therapeutic targets. Ubiquitin-specific protease 4 (USP4), as a key regulator of protein stability, has been proven to be closely asso...

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Bibliographic Details
Main Authors: Siqi Chen, Jinfeng Yang, Guangying Qi, Jiawei Zhao, Yujing Chen, Xiaotong Guo, Juzheng Zhang, Jinfeng Gan, Zhiyuan Jian, Jiamin Jin
Format: Article
Language:English
Published: Springer 2025-03-01
Series:Discover Oncology
Subjects:
Evodiamine
USP4
SOX9
Stemness
Colorectal cancer
Online Access:https://doi.org/10.1007/s12672-025-02183-1
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