Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>

Despite extensive research on <i>Bacillus</i> sp. as lignin degraders, the enzyme mechanisms involved, particularly in <i>Bacillus cereus</i> isolated from termite guts, remain unclear. In this study, the selected Bacillus cereus was fermented to extract the lignin-degrading...

Full description

Saved in:
Bibliographic Details
Main Authors: Sharfina Mutia Syarifah, Ashuvila Mohd Aripin, Nadiah Ishak, Nosa Septiana Anindita, Mohd Firdaus Abdul-Wahab, Angzzas Sari Mohd Kassim
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Engineering Proceedings
Subjects:
Online Access:https://www.mdpi.com/2673-4591/84/1/41
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849432629476065280
author Sharfina Mutia Syarifah
Ashuvila Mohd Aripin
Nadiah Ishak
Nosa Septiana Anindita
Mohd Firdaus Abdul-Wahab
Angzzas Sari Mohd Kassim
author_facet Sharfina Mutia Syarifah
Ashuvila Mohd Aripin
Nadiah Ishak
Nosa Septiana Anindita
Mohd Firdaus Abdul-Wahab
Angzzas Sari Mohd Kassim
author_sort Sharfina Mutia Syarifah
collection DOAJ
description Despite extensive research on <i>Bacillus</i> sp. as lignin degraders, the enzyme mechanisms involved, particularly in <i>Bacillus cereus</i> isolated from termite guts, remain unclear. In this study, the selected Bacillus cereus was fermented to extract the lignin-degrading enzymes to identify the enzymes responsible for lignin degradation using the sample substrate empty fruit bunch (EFB) as their sole carbon source. After 7 days of submerged fermentation (SmF), the crude enzyme was extracted, and SDS-PAGE gel was used to determine the weight of the proteins, and bands with sizes of 20 kDa–97 kDa were extracted for further analysis. The extracted proteins were partially characterized and sequenced using liquid chromatography–mass spectrometry (LC–MS/MS). The results identified 11 enzymes that are responsible for lignin degradation, such as 4-aminobutyrate aminotransferase (GABA), amidohydrolase, chemotaxis protein, serine hydrolase, GMC family protein, glycosyltransferase, phosphate binding protein PstS, ABC transporter ATP-binding protein, heme peroxidase, nitrate reductase, and nitrite reductase. The value of the mutual relationships between all the enzymes in <i>Bacillus cereus</i> indicates the synergistic mechanism under carbon scrutinization. Also, the peptides sequenced in this study identified various uncharacterized proteins and hypothetical proteins that might not be discovered for their protein functions. Further analysis is essential to uncover more lignin degradation enzymes that can work synergically for paper and pulp bioprocessing.
format Article
id doaj-art-426e6df3acd24bccaeeb8b1d16cb9a69
institution Kabale University
issn 2673-4591
language English
publishDate 2025-02-01
publisher MDPI AG
record_format Article
series Engineering Proceedings
spelling doaj-art-426e6df3acd24bccaeeb8b1d16cb9a692025-08-20T03:27:18ZengMDPI AGEngineering Proceedings2673-45912025-02-018414110.3390/engproc2025084041Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>Sharfina Mutia Syarifah0Ashuvila Mohd Aripin1Nadiah Ishak2Nosa Septiana Anindita3Mohd Firdaus Abdul-Wahab4Angzzas Sari Mohd Kassim5Biotechnology Study Programme, Faculty of Science and Technology, Universitas ‘Aisyiyah Yogyakarta, Yogyakarta 55292, IndonesiaDepartment of Chemical Engineering Technology, Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, Pagoh 84300, MalaysiaFaculty of Business, Hospitality and Technology, Universiti Islam Melaka, Kuala Sungai Baru 75400, MalaysiaBiotechnology Study Programme, Faculty of Science and Technology, Universitas ‘Aisyiyah Yogyakarta, Yogyakarta 55292, IndonesiaDepartment of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, Skudai 81310, MalaysiaDepartment of Chemical Engineering Technology, Faculty of Engineering Technology, Universiti Tun Hussein Onn Malaysia, Pagoh 84300, MalaysiaDespite extensive research on <i>Bacillus</i> sp. as lignin degraders, the enzyme mechanisms involved, particularly in <i>Bacillus cereus</i> isolated from termite guts, remain unclear. In this study, the selected Bacillus cereus was fermented to extract the lignin-degrading enzymes to identify the enzymes responsible for lignin degradation using the sample substrate empty fruit bunch (EFB) as their sole carbon source. After 7 days of submerged fermentation (SmF), the crude enzyme was extracted, and SDS-PAGE gel was used to determine the weight of the proteins, and bands with sizes of 20 kDa–97 kDa were extracted for further analysis. The extracted proteins were partially characterized and sequenced using liquid chromatography–mass spectrometry (LC–MS/MS). The results identified 11 enzymes that are responsible for lignin degradation, such as 4-aminobutyrate aminotransferase (GABA), amidohydrolase, chemotaxis protein, serine hydrolase, GMC family protein, glycosyltransferase, phosphate binding protein PstS, ABC transporter ATP-binding protein, heme peroxidase, nitrate reductase, and nitrite reductase. The value of the mutual relationships between all the enzymes in <i>Bacillus cereus</i> indicates the synergistic mechanism under carbon scrutinization. Also, the peptides sequenced in this study identified various uncharacterized proteins and hypothetical proteins that might not be discovered for their protein functions. Further analysis is essential to uncover more lignin degradation enzymes that can work synergically for paper and pulp bioprocessing.https://www.mdpi.com/2673-4591/84/1/41<i>Bacillus cereus</i>delignificationenzyme expression
spellingShingle Sharfina Mutia Syarifah
Ashuvila Mohd Aripin
Nadiah Ishak
Nosa Septiana Anindita
Mohd Firdaus Abdul-Wahab
Angzzas Sari Mohd Kassim
Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
Engineering Proceedings
<i>Bacillus cereus</i>
delignification
enzyme expression
title Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
title_full Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
title_fullStr Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
title_full_unstemmed Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
title_short Partial Purification of <i>Bacillus cereus</i> Enzyme Expression for Bio-Pulping of Lignin Degraders Isolated from <i>Coptotermus curvignathus</i>
title_sort partial purification of i bacillus cereus i enzyme expression for bio pulping of lignin degraders isolated from i coptotermus curvignathus i
topic <i>Bacillus cereus</i>
delignification
enzyme expression
url https://www.mdpi.com/2673-4591/84/1/41
work_keys_str_mv AT sharfinamutiasyarifah partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi
AT ashuvilamohdaripin partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi
AT nadiahishak partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi
AT nosaseptianaanindita partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi
AT mohdfirdausabdulwahab partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi
AT angzzassarimohdkassim partialpurificationofibacilluscereusienzymeexpressionforbiopulpingoflignindegradersisolatedfromicoptotermuscurvignathusi