Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma
Aim. To study the parameters of the matrix metalloproteinase (MMP) / tissue inhibitors of metalloproteinase (TIMP) system in assessing the clinical course of pulmonary tuberculoma.Materials and methods. We examined 87 patients (55 men and 32 women), average age 33 [28; 43] years, with a morphologica...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2024-04-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/5530 |
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| author | D. S. Esmedlyaeva N. P. Alekseeva M. Ye. Dyakova D. V. Karostik I. V. Grigoriev E. G. Sokolovich |
| author_facet | D. S. Esmedlyaeva N. P. Alekseeva M. Ye. Dyakova D. V. Karostik I. V. Grigoriev E. G. Sokolovich |
| author_sort | D. S. Esmedlyaeva |
| collection | DOAJ |
| description | Aim. To study the parameters of the matrix metalloproteinase (MMP) / tissue inhibitors of metalloproteinase (TIMP) system in assessing the clinical course of pulmonary tuberculoma.Materials and methods. We examined 87 patients (55 men and 32 women), average age 33 [28; 43] years, with a morphologically and bacteriologically confirmed diagnosis of tuberculoma, who received treatment at St. Petersburg Research Institute of Phthisiopulmonology. In all patients, computed tomography of the chest, fiberoptic bronchoscopy, and lung function tests were performed. In the blood serum, concentrations of MMP-1, -8, -9, and their tissue inhibitor TIMP-1 were determined using ELISA (R&D Systems, USA), and the activity of α2-macroglobulin (MG) was determined by the enzyme assays. For statistical data processing, Statistica 10.0 and R were used.Results. In the study group, single and multiple tuberculomas were revealed in 37 and 63% of cases, respectively, necrotic areas – in 50% of patients, external respiration disorders – in 48% of cases, and catarrhal bronchitis (CB) – in 77% of cases. Tobacco smokers (TS) were identified in 69% of cases. Significant differences between MMP concentrations allowed us to distinguish four patterns from the characteristics adopted for the clinical and radiological assessment of disease intensity. It was shown that an increase in the levels of MMP-1 and MMP-9 can be a predictor of tuberculoma progression caused by a diffuse process with necrotic areas and bronchogenic dissemination (pattern 1, 2). Changes in the levels of MMP-8, TIMP-1 or MG (pattern 3, 4) were associated with permanent exposure to a non-specific component of inflammation (TS or CB).Conclusion. Changes in the MMP / TIMP system parameters can be used as objective laboratory protein biomarkers to assess the clinical course of pulmonary tuberculoma. |
| format | Article |
| id | doaj-art-426e5a669b18431199b911c8d2eec7b3 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-426e5a669b18431199b911c8d2eec7b32025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842024-04-01231778410.20538/1682-0363-2024-1-77-843056Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculomaD. S. Esmedlyaeva0N. P. Alekseeva1M. Ye. Dyakova2D. V. Karostik3I. V. Grigoriev4E. G. Sokolovich5St. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg UniversitySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg UniversityN.N. Petrov National Medical Research Center of Oncology; National Medical Research Center for Phthisiopulmonology and Infectious Diseases; Russian Medical Academy for Continuing Professional EducationAim. To study the parameters of the matrix metalloproteinase (MMP) / tissue inhibitors of metalloproteinase (TIMP) system in assessing the clinical course of pulmonary tuberculoma.Materials and methods. We examined 87 patients (55 men and 32 women), average age 33 [28; 43] years, with a morphologically and bacteriologically confirmed diagnosis of tuberculoma, who received treatment at St. Petersburg Research Institute of Phthisiopulmonology. In all patients, computed tomography of the chest, fiberoptic bronchoscopy, and lung function tests were performed. In the blood serum, concentrations of MMP-1, -8, -9, and their tissue inhibitor TIMP-1 were determined using ELISA (R&D Systems, USA), and the activity of α2-macroglobulin (MG) was determined by the enzyme assays. For statistical data processing, Statistica 10.0 and R were used.Results. In the study group, single and multiple tuberculomas were revealed in 37 and 63% of cases, respectively, necrotic areas – in 50% of patients, external respiration disorders – in 48% of cases, and catarrhal bronchitis (CB) – in 77% of cases. Tobacco smokers (TS) were identified in 69% of cases. Significant differences between MMP concentrations allowed us to distinguish four patterns from the characteristics adopted for the clinical and radiological assessment of disease intensity. It was shown that an increase in the levels of MMP-1 and MMP-9 can be a predictor of tuberculoma progression caused by a diffuse process with necrotic areas and bronchogenic dissemination (pattern 1, 2). Changes in the levels of MMP-8, TIMP-1 or MG (pattern 3, 4) were associated with permanent exposure to a non-specific component of inflammation (TS or CB).Conclusion. Changes in the MMP / TIMP system parameters can be used as objective laboratory protein biomarkers to assess the clinical course of pulmonary tuberculoma.https://bulletin.ssmu.ru/jour/article/view/5530extracellular matrixmatrix metalloproteinasestissue inhibitors of metalloproteinasespulmonary tuberculoma |
| spellingShingle | D. S. Esmedlyaeva N. P. Alekseeva M. Ye. Dyakova D. V. Karostik I. V. Grigoriev E. G. Sokolovich Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma Бюллетень сибирской медицины extracellular matrix matrix metalloproteinases tissue inhibitors of metalloproteinases pulmonary tuberculoma |
| title | Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma |
| title_full | Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma |
| title_fullStr | Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma |
| title_full_unstemmed | Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma |
| title_short | Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma |
| title_sort | parameters of the mmp timp system in assessing the clinical course of pulmonary tuberculoma |
| topic | extracellular matrix matrix metalloproteinases tissue inhibitors of metalloproteinases pulmonary tuberculoma |
| url | https://bulletin.ssmu.ru/jour/article/view/5530 |
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