Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach
Normally, hydroxyapatite (HAp) ceramics exhibit several mechanical properties lower than the human bone. To enhance the mechanical properties, several improvement techniques have been proposed. In this work, we demonstrated an alternative approach to improve the mechanical performance of HAp ceramic...
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| Format: | Article |
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Elsevier
2025-07-01
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| Series: | Journal of Materials Research and Technology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2238785425016862 |
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| author | Phanrawee Sriprapha Kamonpan Pengpat Komsanti Chokethawai Sujitra Tandorn Burit Kongmali Chamnan Randorn Nopakarn Chandet Waraporn Boontakam Gobwute Rujijanagul |
| author_facet | Phanrawee Sriprapha Kamonpan Pengpat Komsanti Chokethawai Sujitra Tandorn Burit Kongmali Chamnan Randorn Nopakarn Chandet Waraporn Boontakam Gobwute Rujijanagul |
| author_sort | Phanrawee Sriprapha |
| collection | DOAJ |
| description | Normally, hydroxyapatite (HAp) ceramics exhibit several mechanical properties lower than the human bone. To enhance the mechanical properties, several improvement techniques have been proposed. In this work, we demonstrated an alternative approach to improve the mechanical performance of HAp ceramics by incorporating a self-phase nanoparticle additive. Specifically, micron-sized HAp (m-HAp) derived from bovine bone was combined with nano-hydroxyapatite (n-HAp), synthesized via a peroxide-based method. The resulting powder mixture was compacted into disk-shaped pellets using conventional uniaxial cold pressing and subsequently sintered at 1200 °C under atmospheric conditions. Effects of the n-HAp additive on the properties of the ceramics were investigated. All ceramic samples contained the main phase of HAp. However, the amount of β-tricalcium phosphate (β-TCP) phase increased with the amount of n-HAp. The bulk density and mechanical properties of the ceramics improved, achieving optimal levels in samples containing 50 wt% n-HAp, while their grain size slightly increased. The observed improvements were linked to the nano-additive's significant promotion of surface diffusion during the sintering process. Bio-properties testing, including simulated body fluid (SBF), MTT assay, and protein adsorption tests demonstrated that the investigated HAp ceramic samples exhibited a desired bio-performance. Although the proposed technique could positively impact the properties of HAp ceramics, which are a type of biomaterial, it should also be improved to enhance the properties of other types of ceramics with various applications. |
| format | Article |
| id | doaj-art-426dd4b46beb4db68bbdc59f4d2f97a3 |
| institution | Kabale University |
| issn | 2238-7854 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Materials Research and Technology |
| spelling | doaj-art-426dd4b46beb4db68bbdc59f4d2f97a32025-08-20T03:29:10ZengElsevierJournal of Materials Research and Technology2238-78542025-07-01373801381410.1016/j.jmrt.2025.07.028Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approachPhanrawee Sriprapha0Kamonpan Pengpat1Komsanti Chokethawai2Sujitra Tandorn3Burit Kongmali4Chamnan Randorn5Nopakarn Chandet6Waraporn Boontakam7Gobwute Rujijanagul8Department of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, ThailandDepartment of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, ThailandDepartment of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand; Materials Science Research Center, Faculty of Science, Chiang Mai University, 50200, Chiang Mai, ThailandOffice of Research Administration, Chiang Mai University, Chiang Mai, 50200, ThailandNational Center for Genetic Engineering and Biotechnology, 113 Thailand Science Park, Phahonyothin Road, Khlong Nueang, Khlong Luang, Pathumthani, 12120, ThailandMaterials Science Research Center, Faculty of Science, Chiang Mai University, 50200, Chiang Mai, Thailand; Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, ThailandDepartment of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, ThailandDepartment of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, ThailandDepartment of Physics and Materials Science, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand; Materials Science Research Center, Faculty of Science, Chiang Mai University, 50200, Chiang Mai, Thailand; Multidisciplinary Research Institute (MDRI), Chiang Mai University, Chiang Mai, 50200, Thailand; Corresponding author. Department of Physics and Materials Science, Chiang Mai University, Chiang Mai, 50200, Thailand.Normally, hydroxyapatite (HAp) ceramics exhibit several mechanical properties lower than the human bone. To enhance the mechanical properties, several improvement techniques have been proposed. In this work, we demonstrated an alternative approach to improve the mechanical performance of HAp ceramics by incorporating a self-phase nanoparticle additive. Specifically, micron-sized HAp (m-HAp) derived from bovine bone was combined with nano-hydroxyapatite (n-HAp), synthesized via a peroxide-based method. The resulting powder mixture was compacted into disk-shaped pellets using conventional uniaxial cold pressing and subsequently sintered at 1200 °C under atmospheric conditions. Effects of the n-HAp additive on the properties of the ceramics were investigated. All ceramic samples contained the main phase of HAp. However, the amount of β-tricalcium phosphate (β-TCP) phase increased with the amount of n-HAp. The bulk density and mechanical properties of the ceramics improved, achieving optimal levels in samples containing 50 wt% n-HAp, while their grain size slightly increased. The observed improvements were linked to the nano-additive's significant promotion of surface diffusion during the sintering process. Bio-properties testing, including simulated body fluid (SBF), MTT assay, and protein adsorption tests demonstrated that the investigated HAp ceramic samples exhibited a desired bio-performance. Although the proposed technique could positively impact the properties of HAp ceramics, which are a type of biomaterial, it should also be improved to enhance the properties of other types of ceramics with various applications.http://www.sciencedirect.com/science/article/pii/S2238785425016862HydroxyapatiteNanoparticlesBio-ceramicsMechanical propertiesBio-properties |
| spellingShingle | Phanrawee Sriprapha Kamonpan Pengpat Komsanti Chokethawai Sujitra Tandorn Burit Kongmali Chamnan Randorn Nopakarn Chandet Waraporn Boontakam Gobwute Rujijanagul Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach Journal of Materials Research and Technology Hydroxyapatite Nanoparticles Bio-ceramics Mechanical properties Bio-properties |
| title | Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach |
| title_full | Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach |
| title_fullStr | Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach |
| title_full_unstemmed | Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach |
| title_short | Enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self-phase-nanoparticle additive approach |
| title_sort | enhancement of the mechanical and biological properties of hydroxyapatite ceramics via a self phase nanoparticle additive approach |
| topic | Hydroxyapatite Nanoparticles Bio-ceramics Mechanical properties Bio-properties |
| url | http://www.sciencedirect.com/science/article/pii/S2238785425016862 |
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