Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy
Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during in vivo delivery. Here, we developed an enzyme delivering nanoplatform (GCI@RPCM) with great in vivo stability and achieve NIR-tr...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S259000642400406X |
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| author | Yuqiong Xia Chang Liu Xuejuan Zhao Keyun Wu Jianxia Cao Yutian Cao Cheng Zhu Xianghan Zhang |
| author_facet | Yuqiong Xia Chang Liu Xuejuan Zhao Keyun Wu Jianxia Cao Yutian Cao Cheng Zhu Xianghan Zhang |
| author_sort | Yuqiong Xia |
| collection | DOAJ |
| description | Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during in vivo delivery. Here, we developed an enzyme delivering nanoplatform (GCI@RPCM) with great in vivo stability and achieve NIR-triggered enzyme dynamic therapy. This nanoplatform is created with encapsulation of nature enzymes (glucose oxidase and chloroperoxidase) and photothermal agent (indocyanine green) within tumor targeting and thermo-responsive phase change materials (RPCMs). With NIR irradiation for 10 min, GCI@RPCM can release 41 % of the enzymes and generate abundant reactive oxygen species (ROS), which showed significant tumor cell inhibition. After intravenous injection, GCI@RPCM can efficiently accumulate at the tumor site and local NIR treatment resulted in complete tumor eradication without detectable systemic toxicity. This study provides a highly stable and NIR-controllable smart delivery system and achieve enzyme dynamic therapy for enhanced breast cancer therapy. |
| format | Article |
| id | doaj-art-4269257ec3d6472e8a82422be7e1b498 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-4269257ec3d6472e8a82422be7e1b4982025-08-20T02:37:43ZengElsevierMaterials Today Bio2590-00642024-12-012910134510.1016/j.mtbio.2024.101345Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapyYuqiong Xia0Chang Liu1Xuejuan Zhao2Keyun Wu3Jianxia Cao4Yutian Cao5Cheng Zhu6Xianghan Zhang7Engineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China; Guangzhou Institute of Technology, Xidian University, Guangzhou, Guangdong, 510555, China; Corresponding author. Engineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.Engineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, ChinaEngineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, ChinaEngineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, ChinaEngineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, ChinaEngineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China; Guangzhou Institute of Technology, Xidian University, Guangzhou, Guangdong, 510555, ChinaTianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China; Corresponding author. Tianjin Key Laboratory of Function and Application of Biological Macromolecular Structures, School of Life Sciences, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China.Engineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China; Guangzhou Institute of Technology, Xidian University, Guangzhou, Guangdong, 510555, China; Corresponding author. Engineering Research Center of Molecular- and Neuro-imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi, 710126, China.Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during in vivo delivery. Here, we developed an enzyme delivering nanoplatform (GCI@RPCM) with great in vivo stability and achieve NIR-triggered enzyme dynamic therapy. This nanoplatform is created with encapsulation of nature enzymes (glucose oxidase and chloroperoxidase) and photothermal agent (indocyanine green) within tumor targeting and thermo-responsive phase change materials (RPCMs). With NIR irradiation for 10 min, GCI@RPCM can release 41 % of the enzymes and generate abundant reactive oxygen species (ROS), which showed significant tumor cell inhibition. After intravenous injection, GCI@RPCM can efficiently accumulate at the tumor site and local NIR treatment resulted in complete tumor eradication without detectable systemic toxicity. This study provides a highly stable and NIR-controllable smart delivery system and achieve enzyme dynamic therapy for enhanced breast cancer therapy.http://www.sciencedirect.com/science/article/pii/S259000642400406XPhase change materialEnzyme dynamic therapyEnzyme deliveryNear infrared responsive |
| spellingShingle | Yuqiong Xia Chang Liu Xuejuan Zhao Keyun Wu Jianxia Cao Yutian Cao Cheng Zhu Xianghan Zhang Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy Materials Today Bio Phase change material Enzyme dynamic therapy Enzyme delivery Near infrared responsive |
| title | Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| title_full | Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| title_fullStr | Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| title_full_unstemmed | Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| title_short | Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| title_sort | highly stable and near infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy |
| topic | Phase change material Enzyme dynamic therapy Enzyme delivery Near infrared responsive |
| url | http://www.sciencedirect.com/science/article/pii/S259000642400406X |
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