Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D
Aim: The present study aimed to correlate the association between serum iron, serum ferritin, serum albumin, and Vitamin D with early childhood caries (ECC). Materials and Methods: This study was a single-blinded randomized control trial. A total of 200 children aged between 3–6 years were screened...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_402_24 |
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| author | Vasundhara Megha Jeevendra Nath Shukla Rajat Kumar Singh Chitrita Gupta Mukherjee Siddharth Anand Aparna Singh |
| author_facet | Vasundhara Megha Jeevendra Nath Shukla Rajat Kumar Singh Chitrita Gupta Mukherjee Siddharth Anand Aparna Singh |
| author_sort | Vasundhara Megha |
| collection | DOAJ |
| description | Aim:
The present study aimed to correlate the association between serum iron, serum ferritin, serum albumin, and Vitamin D with early childhood caries (ECC).
Materials and Methods:
This study was a single-blinded randomized control trial. A total of 200 children aged between 3–6 years were screened for ECC, according to the AAPD guidelines. Out of 200 children, a total of 177 children fulfilled the inclusion criteria. They were divided into two groups: Group 1 consisted of 99 children with ECC and Group 2 (control group) with 78 children. The decayed, extracted because of caries, and filled primary teeth (deft) index were recorded from these children. Blood samples (approximately 2 ml) were collected by an expert nurse in the morning to determine serum levels of iron, ferritin, albumin, and Vitamin D. The data was statistically analyzed using the Mann–Whitney U test, and P value 0.05 was considered significant.
Results:
The mean deft score was 4.83 (±3.54). The mean value of serum iron was 64.66 (±8.35) μg/dl, serum albumin 3.88 (±0.57) gm/dl, and serum ferritin 29.19 (±42.11) ng/ml in ECC children, whereas mean serum iron was 67.78 (±6.17), serum albumin 3.82 (±0.62) gm/dl, and serum ferritin 26.38 (±23.04) ng/ml in caries-free children. Statistically, no significant relationship was observed between serum iron (P = 0.066), serum albumin (P = 0.448), and serum ferritin (P = 0.192) with ECC. The mean value of Vitamin D was 17.44 (±7.59) ng/ml in ECC children and 35.9 (±9.56) in caries-free children who were significantly low in comparison with the non-ECC subjects (P < 0.0001).
Conclusion:
The present study suggests no relationship between serum iron, serum albumin, and serum ferritin with ECC, whereas Vitamin D had an inverse relationship with ECC.
Clinical Significance:
This study sets a benchmark for the dental fraternity and other health specialists to analyze serum iron, serum ferritin, serum albumin, and Vitamin D levels, while generally treating pediatric patients with or without dental caries. Oral health education campaigns should be conducted for public awareness about the importance of iron, ferritin, albumin, and Vitamin D. |
| format | Article |
| id | doaj-art-42674d86cac043fbb2039935b878300c |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-42674d86cac043fbb2039935b878300c2025-02-11T12:52:44ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-01-0114111512010.4103/jfmpc.jfmpc_402_24Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin DVasundhara MeghaJeevendra Nath ShuklaRajat Kumar SinghChitrita Gupta MukherjeeSiddharth AnandAparna SinghAim: The present study aimed to correlate the association between serum iron, serum ferritin, serum albumin, and Vitamin D with early childhood caries (ECC). Materials and Methods: This study was a single-blinded randomized control trial. A total of 200 children aged between 3–6 years were screened for ECC, according to the AAPD guidelines. Out of 200 children, a total of 177 children fulfilled the inclusion criteria. They were divided into two groups: Group 1 consisted of 99 children with ECC and Group 2 (control group) with 78 children. The decayed, extracted because of caries, and filled primary teeth (deft) index were recorded from these children. Blood samples (approximately 2 ml) were collected by an expert nurse in the morning to determine serum levels of iron, ferritin, albumin, and Vitamin D. The data was statistically analyzed using the Mann–Whitney U test, and P value 0.05 was considered significant. Results: The mean deft score was 4.83 (±3.54). The mean value of serum iron was 64.66 (±8.35) μg/dl, serum albumin 3.88 (±0.57) gm/dl, and serum ferritin 29.19 (±42.11) ng/ml in ECC children, whereas mean serum iron was 67.78 (±6.17), serum albumin 3.82 (±0.62) gm/dl, and serum ferritin 26.38 (±23.04) ng/ml in caries-free children. Statistically, no significant relationship was observed between serum iron (P = 0.066), serum albumin (P = 0.448), and serum ferritin (P = 0.192) with ECC. The mean value of Vitamin D was 17.44 (±7.59) ng/ml in ECC children and 35.9 (±9.56) in caries-free children who were significantly low in comparison with the non-ECC subjects (P < 0.0001). Conclusion: The present study suggests no relationship between serum iron, serum albumin, and serum ferritin with ECC, whereas Vitamin D had an inverse relationship with ECC. Clinical Significance: This study sets a benchmark for the dental fraternity and other health specialists to analyze serum iron, serum ferritin, serum albumin, and Vitamin D levels, while generally treating pediatric patients with or without dental caries. Oral health education campaigns should be conducted for public awareness about the importance of iron, ferritin, albumin, and Vitamin D.https://journals.lww.com/10.4103/jfmpc.jfmpc_402_24early childhood cariesserum albuminserum ferritinserum ironvitamin d |
| spellingShingle | Vasundhara Megha Jeevendra Nath Shukla Rajat Kumar Singh Chitrita Gupta Mukherjee Siddharth Anand Aparna Singh Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D Journal of Family Medicine and Primary Care early childhood caries serum albumin serum ferritin serum iron vitamin d |
| title | Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D |
| title_full | Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D |
| title_fullStr | Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D |
| title_full_unstemmed | Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D |
| title_short | Early childhood caries and their association with serum iron, serum ferritin, serum albumin, and Vitamin D |
| title_sort | early childhood caries and their association with serum iron serum ferritin serum albumin and vitamin d |
| topic | early childhood caries serum albumin serum ferritin serum iron vitamin d |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_402_24 |
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