MicroRNAs as Haematopoiesis Regulators
The production of different types of blood cells including their formation, development, and differentiation is collectively known as haematopoiesis. Blood cells are divided into three lineages erythriod (erythrocytes), lymphoid (B and T cells), and myeloid (granulocytes, megakaryocytes, and macroph...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/695754 |
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| author | Ram Babu Undi Ravinder Kandi Ravi Kumar Gutti |
| author_facet | Ram Babu Undi Ravinder Kandi Ravi Kumar Gutti |
| author_sort | Ram Babu Undi |
| collection | DOAJ |
| description | The production of different types of blood cells including their formation, development, and differentiation is collectively known as haematopoiesis. Blood cells are divided into three lineages erythriod (erythrocytes), lymphoid (B and T cells), and myeloid (granulocytes, megakaryocytes, and macrophages). Haematopoiesis is a complex process regulated by several mechanisms including microRNAs (miRNAs). miRNAs are small RNAs which regulate the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells. Evidence shows that miRNAs play an important role in haematopoiesis; for example, myeloid and erythroid differentiation is blocked by the overexpression of miR-15a. miR-221, miR-222, and miR-24 inhibit the erythropoiesis, whereas miR-150 plays a role in B and T cell differentiation. miR-146 and miR-10a are downregulated in megakaryopoiesis. Aberrant expression of miRNAs was observed in hematological malignancies including chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myelomas, and B cell lymphomas. In this review we have focused on discussing the role of miRNA in haematopoiesis. |
| format | Article |
| id | doaj-art-425f90cea86f45b486f5dfe2d77bab9d |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-425f90cea86f45b486f5dfe2d77bab9d2025-02-03T01:28:15ZengWileyAdvances in Hematology1687-91041687-91122013-01-01201310.1155/2013/695754695754MicroRNAs as Haematopoiesis RegulatorsRam Babu Undi0Ravinder Kandi1Ravi Kumar Gutti2Hematologic Oncology, Stem Cells and Blood Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Andhra Pradesh 500046, IndiaHematologic Oncology, Stem Cells and Blood Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Andhra Pradesh 500046, IndiaHematologic Oncology, Stem Cells and Blood Disorders Laboratory, Department of Biochemistry, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, Andhra Pradesh 500046, IndiaThe production of different types of blood cells including their formation, development, and differentiation is collectively known as haematopoiesis. Blood cells are divided into three lineages erythriod (erythrocytes), lymphoid (B and T cells), and myeloid (granulocytes, megakaryocytes, and macrophages). Haematopoiesis is a complex process regulated by several mechanisms including microRNAs (miRNAs). miRNAs are small RNAs which regulate the expression of a number of genes involved in commitment and differentiation of hematopoietic stem cells. Evidence shows that miRNAs play an important role in haematopoiesis; for example, myeloid and erythroid differentiation is blocked by the overexpression of miR-15a. miR-221, miR-222, and miR-24 inhibit the erythropoiesis, whereas miR-150 plays a role in B and T cell differentiation. miR-146 and miR-10a are downregulated in megakaryopoiesis. Aberrant expression of miRNAs was observed in hematological malignancies including chronic myelogenous leukemia, chronic lymphocytic leukemia, multiple myelomas, and B cell lymphomas. In this review we have focused on discussing the role of miRNA in haematopoiesis.http://dx.doi.org/10.1155/2013/695754 |
| spellingShingle | Ram Babu Undi Ravinder Kandi Ravi Kumar Gutti MicroRNAs as Haematopoiesis Regulators Advances in Hematology |
| title | MicroRNAs as Haematopoiesis Regulators |
| title_full | MicroRNAs as Haematopoiesis Regulators |
| title_fullStr | MicroRNAs as Haematopoiesis Regulators |
| title_full_unstemmed | MicroRNAs as Haematopoiesis Regulators |
| title_short | MicroRNAs as Haematopoiesis Regulators |
| title_sort | micrornas as haematopoiesis regulators |
| url | http://dx.doi.org/10.1155/2013/695754 |
| work_keys_str_mv | AT rambabuundi micrornasashaematopoiesisregulators AT ravinderkandi micrornasashaematopoiesisregulators AT ravikumargutti micrornasashaematopoiesisregulators |