Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness
Topical instillation of cyclosporin A (an anti‐inflammatory drug) is clinically recommended as the first‐line treatment for dry eye disease. Nevertheless, it suffers from poor ocular drug retention and cannot comprehensively address corneal dryness‐related symptoms such as oxidative stress, angiogen...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2025-02-01
|
| Series: | Small Structures |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/sstr.202400484 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542163148210176 |
|---|---|
| author | Sandip Ghosh Yun‐Han Su Chia‐Jung Yang Jui‐Yang Lai |
| author_facet | Sandip Ghosh Yun‐Han Su Chia‐Jung Yang Jui‐Yang Lai |
| author_sort | Sandip Ghosh |
| collection | DOAJ |
| description | Topical instillation of cyclosporin A (an anti‐inflammatory drug) is clinically recommended as the first‐line treatment for dry eye disease. Nevertheless, it suffers from poor ocular drug retention and cannot comprehensively address corneal dryness‐related symptoms such as oxidative stress, angiogenesis, and neurodegeneration. Inspired by nanotechnology‐mediated material/biological interactions, in this study, a highly adhesive metallic nanoplatform with an urchin‐like structure is designed for topical quercetin administration in dry eye therapy. The gold nanostructures with the most pronounced branch lengths exhibit the strongest cytoadhesion and bioadhesion capabilities, which significantly enhance the corneal retention of nano‐urchins by 150‐fold at 7 days post‐instillation compared with smooth‐surfaced gold nanoparticles. In a rabbit model of corneal dryness, topical single‐dose nanoformulation (high quercetin‐functionalized gold nano‐urchins (NU‐Q(H))) demonstrated remarkable efficacy in stimulating tear production (30‐fold improvement), inhibiting inflammatory IL‐6 expression (49‐fold improvement), attenuating pathological angiogenesis (32‐fold improvement), and promoting nerve regeneration (18‐fold improvement) compared to high quercetin‐functionalized gold nanoparticles (NP‐Q(H)). In particular, the integrity of the ocular surface, tear film, and meibomian gland is restored to levels similar to those in healthy rabbits. These findings suggest the promising potential of nanobiomaterial structural engineering in developing highly adhesive metallic nanomedicines as long‐acting eye‐drop formulations for disease treatment applications. |
| format | Article |
| id | doaj-art-4252e4095f534032a6d55a2e338a8600 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-4252e4095f534032a6d55a2e338a86002025-02-04T08:10:21ZengWiley-VCHSmall Structures2688-40622025-02-0162n/an/a10.1002/sstr.202400484Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal DrynessSandip Ghosh0Yun‐Han Su1Chia‐Jung Yang2Jui‐Yang Lai3Department of Biomedical Engineering Chang Gung University Taoyuan 33302 TaiwanDepartment of Biomedical Engineering Chang Gung University Taoyuan 33302 TaiwanDepartment of Biomedical Engineering Chang Gung University Taoyuan 33302 TaiwanDepartment of Biomedical Engineering Chang Gung University Taoyuan 33302 TaiwanTopical instillation of cyclosporin A (an anti‐inflammatory drug) is clinically recommended as the first‐line treatment for dry eye disease. Nevertheless, it suffers from poor ocular drug retention and cannot comprehensively address corneal dryness‐related symptoms such as oxidative stress, angiogenesis, and neurodegeneration. Inspired by nanotechnology‐mediated material/biological interactions, in this study, a highly adhesive metallic nanoplatform with an urchin‐like structure is designed for topical quercetin administration in dry eye therapy. The gold nanostructures with the most pronounced branch lengths exhibit the strongest cytoadhesion and bioadhesion capabilities, which significantly enhance the corneal retention of nano‐urchins by 150‐fold at 7 days post‐instillation compared with smooth‐surfaced gold nanoparticles. In a rabbit model of corneal dryness, topical single‐dose nanoformulation (high quercetin‐functionalized gold nano‐urchins (NU‐Q(H))) demonstrated remarkable efficacy in stimulating tear production (30‐fold improvement), inhibiting inflammatory IL‐6 expression (49‐fold improvement), attenuating pathological angiogenesis (32‐fold improvement), and promoting nerve regeneration (18‐fold improvement) compared to high quercetin‐functionalized gold nanoparticles (NP‐Q(H)). In particular, the integrity of the ocular surface, tear film, and meibomian gland is restored to levels similar to those in healthy rabbits. These findings suggest the promising potential of nanobiomaterial structural engineering in developing highly adhesive metallic nanomedicines as long‐acting eye‐drop formulations for disease treatment applications.https://doi.org/10.1002/sstr.202400484branch lengthcorneal drynessgold nano‐urchinhighly adhesive nanoplatformlong‐acting topical pharmacotherapy |
| spellingShingle | Sandip Ghosh Yun‐Han Su Chia‐Jung Yang Jui‐Yang Lai Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness Small Structures branch length corneal dryness gold nano‐urchin highly adhesive nanoplatform long‐acting topical pharmacotherapy |
| title | Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness |
| title_full | Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness |
| title_fullStr | Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness |
| title_full_unstemmed | Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness |
| title_short | Design of Highly Adhesive Urchin‐Like Gold Nanostructures for Effective Topical Drug Administration and Symptomatic Relief of Corneal Dryness |
| title_sort | design of highly adhesive urchin like gold nanostructures for effective topical drug administration and symptomatic relief of corneal dryness |
| topic | branch length corneal dryness gold nano‐urchin highly adhesive nanoplatform long‐acting topical pharmacotherapy |
| url | https://doi.org/10.1002/sstr.202400484 |
| work_keys_str_mv | AT sandipghosh designofhighlyadhesiveurchinlikegoldnanostructuresforeffectivetopicaldrugadministrationandsymptomaticreliefofcornealdryness AT yunhansu designofhighlyadhesiveurchinlikegoldnanostructuresforeffectivetopicaldrugadministrationandsymptomaticreliefofcornealdryness AT chiajungyang designofhighlyadhesiveurchinlikegoldnanostructuresforeffectivetopicaldrugadministrationandsymptomaticreliefofcornealdryness AT juiyanglai designofhighlyadhesiveurchinlikegoldnanostructuresforeffectivetopicaldrugadministrationandsymptomaticreliefofcornealdryness |