Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum
Pentatricopeptide repeat (PPR) proteins are RNA binding proteins with functions in organelle RNA metabolism. They are found in all eukaryotes but have been most extensively studied in plants. We report on the identification of 12 PPR-encoding genes in the genome of the protist Dictyostelium discoide...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2013/586498 |
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| _version_ | 1832555104475021312 |
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| author | Sam Manna Jessica Brewster Christian Barth |
| author_facet | Sam Manna Jessica Brewster Christian Barth |
| author_sort | Sam Manna |
| collection | DOAJ |
| description | Pentatricopeptide repeat (PPR) proteins are RNA binding proteins with functions in organelle RNA metabolism. They are found in all eukaryotes but have been most extensively studied in plants. We report on the identification of 12 PPR-encoding genes in the genome of the protist Dictyostelium discoideum, with potential homologs in other members of the same lineage and some predicted novel functions for the encoded gene products in protists. For one of the gene products, we show that it localizes to the mitochondria, and we also demonstrate that antisense inhibition of its expression leads to slower growth, a phenotype associated with mitochondrial dysfunction. |
| format | Article |
| id | doaj-art-424f43e5f5bb43fa9c558c3df19734d2 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-424f43e5f5bb43fa9c558c3df19734d22025-02-03T05:49:35ZengWileyInternational Journal of Genomics2314-436X2314-43782013-01-01201310.1155/2013/586498586498Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideumSam Manna0Jessica Brewster1Christian Barth2Department of Microbiology, Thomas Cherry Building, La Trobe University, Kingsbury Drive, Bundoora, VIC 3086, AustraliaDepartment of Microbiology, Thomas Cherry Building, La Trobe University, Kingsbury Drive, Bundoora, VIC 3086, AustraliaDepartment of Microbiology, Thomas Cherry Building, La Trobe University, Kingsbury Drive, Bundoora, VIC 3086, AustraliaPentatricopeptide repeat (PPR) proteins are RNA binding proteins with functions in organelle RNA metabolism. They are found in all eukaryotes but have been most extensively studied in plants. We report on the identification of 12 PPR-encoding genes in the genome of the protist Dictyostelium discoideum, with potential homologs in other members of the same lineage and some predicted novel functions for the encoded gene products in protists. For one of the gene products, we show that it localizes to the mitochondria, and we also demonstrate that antisense inhibition of its expression leads to slower growth, a phenotype associated with mitochondrial dysfunction.http://dx.doi.org/10.1155/2013/586498 |
| spellingShingle | Sam Manna Jessica Brewster Christian Barth Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum International Journal of Genomics |
| title | Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum |
| title_full | Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum |
| title_fullStr | Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum |
| title_full_unstemmed | Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum |
| title_short | Identification of Pentatricopeptide Repeat Proteins in the Model Organism Dictyostelium discoideum |
| title_sort | identification of pentatricopeptide repeat proteins in the model organism dictyostelium discoideum |
| url | http://dx.doi.org/10.1155/2013/586498 |
| work_keys_str_mv | AT sammanna identificationofpentatricopeptiderepeatproteinsinthemodelorganismdictyosteliumdiscoideum AT jessicabrewster identificationofpentatricopeptiderepeatproteinsinthemodelorganismdictyosteliumdiscoideum AT christianbarth identificationofpentatricopeptiderepeatproteinsinthemodelorganismdictyosteliumdiscoideum |