Developing drug-like single-domain antibodies (VHH) from in vitro libraries

Developing drug-like single-domain antibodies (VHH) from in vitro libraries

Here, we describe a new VHH library for therapeutic discovery which optimizes humanness, stability, affinity, diversity, developability, and facile purification using protein A in the absence of an Fc domain. Four therapeutic humanized VHHs were used as scaffolds, into which we inserted human HCDR1s...

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Bibliographic Details
Main Authors: M. Frank Erasmus, Andre A. R. Teixeira, Esteban Molina, Luis Antonio Rodriguez Carnero, Jianquan Li, David Knight, Roberto Di Niro, Camila Leal-Lopes, Adeline Fanni, Hallie Troell, Ashley DeAguero, Laura Spector, Sara D’Angelo, Fortunato Ferrara, Andrew R. M. Bradbury
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Antibody
camelid
drug discovery
phage display
single domain
VHH
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2516676
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