Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.

Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance.

The naked mole rat (NMR), Heterocephalus glaber, is known as the longest-lived rodent and is extraordinarily resistant to hypoxia and cancer. Here, both NMR embryonic fibroblasts (NEFs) and their mouse counterparts (MEFs) were subjected to anoxic conditions (0% O2, 5% CO2). A combination of comparat...

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Bibliographic Details
Main Authors: Juan Du, Weiqiang Liu, Meng Li, Zihao Li, Xuanjing Li, Yichen Dai, Gaoming Liu, Xiao Wang, Pingfen Zhu, Vadim N Gladyshev, Xuming Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002778
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