<i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment
The Fragile X Mental Retardation 1 (<i data-eusoft-scrollable-element="1">FMR1</i>) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for canc...
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MDPI AG
2025-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/6/779 |
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| author | Renbin Zhou Hao Lin Xinyu Dou Bang Zeng Xinyi Zhao Lei Ma Drissa Diarra Bing Liu Wei-Wei Deng Tianfu Wu |
| author_facet | Renbin Zhou Hao Lin Xinyu Dou Bang Zeng Xinyi Zhao Lei Ma Drissa Diarra Bing Liu Wei-Wei Deng Tianfu Wu |
| author_sort | Renbin Zhou |
| collection | DOAJ |
| description | The Fragile X Mental Retardation 1 (<i data-eusoft-scrollable-element="1">FMR1</i>) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for cancer biology. <i data-eusoft-scrollable-element="1">FMR1</i> encodes the Fragile X mental retardation protein (FMRP), an RNA-binding protein that controls various cellular processes, including translation, synaptic plasticity, and RNA metabolism. Recent studies have uncovered novel links between <i data-eusoft-scrollable-element="1">FMR1</i>, metabolic regulation, and tumorigenesis. This review discusses the role of <i data-eusoft-scrollable-element="1">FMR1</i> in cellular metabolism and its potential involvement in cancer, focusing on glycolysis, mitochondrial metabolism, lipid metabolism, immune cell metabolism, and tumor immune evasion, and as a potential target to enhance immunotherapy, and highlights future research directions to elucidate its mechanistic roles in cancer. |
| format | Article |
| id | doaj-art-4243097a41b7420fbfba5fe774d4bd1d |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-4243097a41b7420fbfba5fe774d4bd1d2025-08-20T03:27:21ZengMDPI AGBiomolecules2218-273X2025-05-0115677910.3390/biom15060779<i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor MicroenvironmentRenbin Zhou0Hao Lin1Xinyu Dou2Bang Zeng3Xinyi Zhao4Lei Ma5Drissa Diarra6Bing Liu7Wei-Wei Deng8Tianfu Wu9State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Hongshan District, Wuhan 430079, ChinaThe Fragile X Mental Retardation 1 (<i data-eusoft-scrollable-element="1">FMR1</i>) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for cancer biology. <i data-eusoft-scrollable-element="1">FMR1</i> encodes the Fragile X mental retardation protein (FMRP), an RNA-binding protein that controls various cellular processes, including translation, synaptic plasticity, and RNA metabolism. Recent studies have uncovered novel links between <i data-eusoft-scrollable-element="1">FMR1</i>, metabolic regulation, and tumorigenesis. This review discusses the role of <i data-eusoft-scrollable-element="1">FMR1</i> in cellular metabolism and its potential involvement in cancer, focusing on glycolysis, mitochondrial metabolism, lipid metabolism, immune cell metabolism, and tumor immune evasion, and as a potential target to enhance immunotherapy, and highlights future research directions to elucidate its mechanistic roles in cancer.https://www.mdpi.com/2218-273X/15/6/779FMRPmetabolismtumorimmune escapecancer therapytumor microenvironment |
| spellingShingle | Renbin Zhou Hao Lin Xinyu Dou Bang Zeng Xinyi Zhao Lei Ma Drissa Diarra Bing Liu Wei-Wei Deng Tianfu Wu <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment Biomolecules FMRP metabolism tumor immune escape cancer therapy tumor microenvironment |
| title | <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment |
| title_full | <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment |
| title_fullStr | <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment |
| title_full_unstemmed | <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment |
| title_short | <i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment |
| title_sort | i fmr1 i a neurodevelopmental factor regulating cell metabolism in the tumor microenvironment |
| topic | FMRP metabolism tumor immune escape cancer therapy tumor microenvironment |
| url | https://www.mdpi.com/2218-273X/15/6/779 |
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