<i>FMR1</i>: A Neurodevelopmental Factor Regulating Cell Metabolism in the Tumor Microenvironment
The Fragile X Mental Retardation 1 (<i data-eusoft-scrollable-element="1">FMR1</i>) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for canc...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-05-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/15/6/779 |
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| Summary: | The Fragile X Mental Retardation 1 (<i data-eusoft-scrollable-element="1">FMR1</i>) gene is well-known for its role in Fragile X syndrome, a neurodevelopmental disorder, but emerging evidence suggests its involvement in regulating cellular metabolism, with implications for cancer biology. <i data-eusoft-scrollable-element="1">FMR1</i> encodes the Fragile X mental retardation protein (FMRP), an RNA-binding protein that controls various cellular processes, including translation, synaptic plasticity, and RNA metabolism. Recent studies have uncovered novel links between <i data-eusoft-scrollable-element="1">FMR1</i>, metabolic regulation, and tumorigenesis. This review discusses the role of <i data-eusoft-scrollable-element="1">FMR1</i> in cellular metabolism and its potential involvement in cancer, focusing on glycolysis, mitochondrial metabolism, lipid metabolism, immune cell metabolism, and tumor immune evasion, and as a potential target to enhance immunotherapy, and highlights future research directions to elucidate its mechanistic roles in cancer. |
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| ISSN: | 2218-273X |