The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients
Radiosurgery (SRS) is a primary treatment for intracranial metastatic disease, but it can lead to cerebral radiation necrosis (RN) in approximately 25% of cases. Unlike tumor progression (TP), which indicates a lack of response to treatment, RN suggests an effective SRS response. Differentiating RN...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Clinical and Translational Neuroscience |
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| Online Access: | https://www.mdpi.com/2514-183X/9/1/10 |
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| author | Joseph P. Antonios Nana Adenu-Mensah Brianna C. Theriault Miguel Millares-Chavez Anita Huttner Mariam Aboian Veronica L. Chiang |
| author_facet | Joseph P. Antonios Nana Adenu-Mensah Brianna C. Theriault Miguel Millares-Chavez Anita Huttner Mariam Aboian Veronica L. Chiang |
| author_sort | Joseph P. Antonios |
| collection | DOAJ |
| description | Radiosurgery (SRS) is a primary treatment for intracranial metastatic disease, but it can lead to cerebral radiation necrosis (RN) in approximately 25% of cases. Unlike tumor progression (TP), which indicates a lack of response to treatment, RN suggests an effective SRS response. Differentiating RN from TP is challenging using standard radiological imaging, often necessitating surgical biopsy. This study investigates the utility of the central vein sign (CVS), a novel MRI biomarker associated with immune infiltrate-rich perivascular spaces, to differentiate RN from TP. Overall, our findings suggest that pre-SRS CVS could serve as a non-invasive marker to distinguish RN from TP, aiding in treatment decisions. Further research is needed to validate CVS as a predictive marker in larger patient cohorts and explore its potential in guiding cancer therapy response. |
| format | Article |
| id | doaj-art-423c0960cf694e9fbd765dcee860a6f2 |
| institution | DOAJ |
| issn | 2514-183X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinical and Translational Neuroscience |
| spelling | doaj-art-423c0960cf694e9fbd765dcee860a6f22025-08-20T02:42:42ZengMDPI AGClinical and Translational Neuroscience2514-183X2025-02-01911010.3390/ctn9010010The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer PatientsJoseph P. Antonios0Nana Adenu-Mensah1Brianna C. Theriault2Miguel Millares-Chavez3Anita Huttner4Mariam Aboian5Veronica L. Chiang6Department of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Pathology, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Radiology, Yale School of Medicine, Yale University, New Haven, CT 06519, USADepartment of Neurosurgery, Yale School of Medicine, Yale University, New Haven, CT 06519, USARadiosurgery (SRS) is a primary treatment for intracranial metastatic disease, but it can lead to cerebral radiation necrosis (RN) in approximately 25% of cases. Unlike tumor progression (TP), which indicates a lack of response to treatment, RN suggests an effective SRS response. Differentiating RN from TP is challenging using standard radiological imaging, often necessitating surgical biopsy. This study investigates the utility of the central vein sign (CVS), a novel MRI biomarker associated with immune infiltrate-rich perivascular spaces, to differentiate RN from TP. Overall, our findings suggest that pre-SRS CVS could serve as a non-invasive marker to distinguish RN from TP, aiding in treatment decisions. Further research is needed to validate CVS as a predictive marker in larger patient cohorts and explore its potential in guiding cancer therapy response.https://www.mdpi.com/2514-183X/9/1/10RN (radiation necrosis)TP (tumor progression)SRS (stereotactic radiosurgery) |
| spellingShingle | Joseph P. Antonios Nana Adenu-Mensah Brianna C. Theriault Miguel Millares-Chavez Anita Huttner Mariam Aboian Veronica L. Chiang The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients Clinical and Translational Neuroscience RN (radiation necrosis) TP (tumor progression) SRS (stereotactic radiosurgery) |
| title | The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients |
| title_full | The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients |
| title_fullStr | The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients |
| title_full_unstemmed | The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients |
| title_short | The Central Vein Sign as a Radiologic Tool to Predict the Diagnosis of Radiation Necrosis in Intracranial Metastatic Cancer Patients |
| title_sort | central vein sign as a radiologic tool to predict the diagnosis of radiation necrosis in intracranial metastatic cancer patients |
| topic | RN (radiation necrosis) TP (tumor progression) SRS (stereotactic radiosurgery) |
| url | https://www.mdpi.com/2514-183X/9/1/10 |
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