Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products

The present work describes a novel, simple, and fast electroanalytical methodology for naproxen (NAP) determination in pharmaceutical formulations and biological fluids in the presence of its degradation products. Carbon paste electrodes (CPEs) modified with different carbon nanomaterials, namely, g...

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Main Authors: Hassan A. M. Hendawy, Waheed M. Salem, Mahmmoud S. Abd-Elmonem, Elmorsy Khaled
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Journal of Analytical Methods in Chemistry
Online Access:http://dx.doi.org/10.1155/2019/5381031
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author Hassan A. M. Hendawy
Waheed M. Salem
Mahmmoud S. Abd-Elmonem
Elmorsy Khaled
author_facet Hassan A. M. Hendawy
Waheed M. Salem
Mahmmoud S. Abd-Elmonem
Elmorsy Khaled
author_sort Hassan A. M. Hendawy
collection DOAJ
description The present work describes a novel, simple, and fast electroanalytical methodology for naproxen (NAP) determination in pharmaceutical formulations and biological fluids in the presence of its degradation products. Carbon paste electrodes (CPEs) modified with different carbon nanomaterials, namely, glassy carbon powder (GCE), multiwall carbon nanotubes (MWCNTs), single-walled carbon nanotubes (SWCNTs), graphene nanosheets (Gr), and graphene oxides (GO) were tested. Comprehensive studies were performed on the electrode matrix composition including the nature of the pasting liquids, pH, carbon nanomaterials, and mode of electrode modification. Two anodic oxidation peaks were recorded at 0.890 and 1.18 V in 1 × 10−1 mol·L−1 phosphate buffer solution at pH 6. Oxidation of naproxen (NAP) is an irreversible diffusion-controlled process. Calibration plots were rectilinear in the concentration ranging from 0.067 to 1.0 µg·mL−1 with correlation coefficient 0.9979. Photodegradation of NAP resulted in disappearance of the oxidation peak at 1.18 V, allowing simultaneous determination of NAP in presence of its degradation product. The achieved high sensitivity and selectivity suggest the application of the proposed protocol for naproxen determination in pharmaceutical preparations and human blood plasma.
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institution Kabale University
issn 2090-8865
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language English
publishDate 2019-01-01
publisher Wiley
record_format Article
series Journal of Analytical Methods in Chemistry
spelling doaj-art-42391f394e3644609a8d5006e8ab2b372025-02-03T05:52:12ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/53810315381031Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation ProductsHassan A. M. Hendawy0Waheed M. Salem1Mahmmoud S. Abd-Elmonem2Elmorsy Khaled3National Organization for Drug Control and Research (NODCAR), P.O. Box 29, Cairo, EgyptChemistry Department, Faculty of Science, Damanhour University, Damanhour, EgyptNational Organization for Drug Control and Research (NODCAR), P.O. Box 29, Cairo, EgyptMicroanalysis Laboratory, Applied Organic Chemistry Department, National Research Centre, El Bohouth St., Dokki, 12622 Giza, EgyptThe present work describes a novel, simple, and fast electroanalytical methodology for naproxen (NAP) determination in pharmaceutical formulations and biological fluids in the presence of its degradation products. Carbon paste electrodes (CPEs) modified with different carbon nanomaterials, namely, glassy carbon powder (GCE), multiwall carbon nanotubes (MWCNTs), single-walled carbon nanotubes (SWCNTs), graphene nanosheets (Gr), and graphene oxides (GO) were tested. Comprehensive studies were performed on the electrode matrix composition including the nature of the pasting liquids, pH, carbon nanomaterials, and mode of electrode modification. Two anodic oxidation peaks were recorded at 0.890 and 1.18 V in 1 × 10−1 mol·L−1 phosphate buffer solution at pH 6. Oxidation of naproxen (NAP) is an irreversible diffusion-controlled process. Calibration plots were rectilinear in the concentration ranging from 0.067 to 1.0 µg·mL−1 with correlation coefficient 0.9979. Photodegradation of NAP resulted in disappearance of the oxidation peak at 1.18 V, allowing simultaneous determination of NAP in presence of its degradation product. The achieved high sensitivity and selectivity suggest the application of the proposed protocol for naproxen determination in pharmaceutical preparations and human blood plasma.http://dx.doi.org/10.1155/2019/5381031
spellingShingle Hassan A. M. Hendawy
Waheed M. Salem
Mahmmoud S. Abd-Elmonem
Elmorsy Khaled
Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
Journal of Analytical Methods in Chemistry
title Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
title_full Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
title_fullStr Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
title_full_unstemmed Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
title_short Nanomaterial-Based Carbon Paste Electrodes for Voltammetric Determination of Naproxen in Presence of Its Degradation Products
title_sort nanomaterial based carbon paste electrodes for voltammetric determination of naproxen in presence of its degradation products
url http://dx.doi.org/10.1155/2019/5381031
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AT waheedmsalem nanomaterialbasedcarbonpasteelectrodesforvoltammetricdeterminationofnaproxeninpresenceofitsdegradationproducts
AT mahmmoudsabdelmonem nanomaterialbasedcarbonpasteelectrodesforvoltammetricdeterminationofnaproxeninpresenceofitsdegradationproducts
AT elmorsykhaled nanomaterialbasedcarbonpasteelectrodesforvoltammetricdeterminationofnaproxeninpresenceofitsdegradationproducts