When less is more: non-monotonic spike sequence processing in neurons.
Fundamental response properties of neurons centrally underly the computational capabilities of both individual nerve cells and neural networks. Most studies on neuronal input-output relations have focused on continuous-time inputs such as constant or noisy sinusoidal currents. Yet, most neurons comm...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-02-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004002&type=printable |
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| _version_ | 1850190653932175360 |
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| author | Hinrich Arnoldt Shuwen Chang Sven Jahnke Birk Urmersbach Holger Taschenberger Marc Timme |
| author_facet | Hinrich Arnoldt Shuwen Chang Sven Jahnke Birk Urmersbach Holger Taschenberger Marc Timme |
| author_sort | Hinrich Arnoldt |
| collection | DOAJ |
| description | Fundamental response properties of neurons centrally underly the computational capabilities of both individual nerve cells and neural networks. Most studies on neuronal input-output relations have focused on continuous-time inputs such as constant or noisy sinusoidal currents. Yet, most neurons communicate via exchanging action potentials (spikes) at discrete times. Here, we systematically analyze the stationary spiking response to regular spiking inputs and reveal that it is generically non-monotonic. Our theoretical analysis shows that the underlying mechanism relies solely on a combination of the discrete nature of the communication by spikes, the capability of locking output to input spikes and limited resources required for spike processing. Numerical simulations of mathematically idealized and biophysically detailed models, as well as neurophysiological experiments confirm and illustrate our theoretical predictions. |
| format | Article |
| id | doaj-art-423909384de040bebda3b7070069a301 |
| institution | OA Journals |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-423909384de040bebda3b7070069a3012025-08-20T02:15:12ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582015-02-01112e100400210.1371/journal.pcbi.1004002When less is more: non-monotonic spike sequence processing in neurons.Hinrich ArnoldtShuwen ChangSven JahnkeBirk UrmersbachHolger TaschenbergerMarc TimmeFundamental response properties of neurons centrally underly the computational capabilities of both individual nerve cells and neural networks. Most studies on neuronal input-output relations have focused on continuous-time inputs such as constant or noisy sinusoidal currents. Yet, most neurons communicate via exchanging action potentials (spikes) at discrete times. Here, we systematically analyze the stationary spiking response to regular spiking inputs and reveal that it is generically non-monotonic. Our theoretical analysis shows that the underlying mechanism relies solely on a combination of the discrete nature of the communication by spikes, the capability of locking output to input spikes and limited resources required for spike processing. Numerical simulations of mathematically idealized and biophysically detailed models, as well as neurophysiological experiments confirm and illustrate our theoretical predictions.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004002&type=printable |
| spellingShingle | Hinrich Arnoldt Shuwen Chang Sven Jahnke Birk Urmersbach Holger Taschenberger Marc Timme When less is more: non-monotonic spike sequence processing in neurons. PLoS Computational Biology |
| title | When less is more: non-monotonic spike sequence processing in neurons. |
| title_full | When less is more: non-monotonic spike sequence processing in neurons. |
| title_fullStr | When less is more: non-monotonic spike sequence processing in neurons. |
| title_full_unstemmed | When less is more: non-monotonic spike sequence processing in neurons. |
| title_short | When less is more: non-monotonic spike sequence processing in neurons. |
| title_sort | when less is more non monotonic spike sequence processing in neurons |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004002&type=printable |
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