Study of T lymphocyte Subsets in children with Beta Thalassemia Major: Correlation with iron overload Adel A. Hagag, Mokhtar A. Hussein, Enaam S. Abed Elbar* From Pediatrics and Clinical Pathology*departments, Faculty of Medicine, Tanta University, Egy
Abstract: Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia that typically requires life long transfusion therapy. Repeated blood transfusions and RBCs hemolysis are the major causes of secondary iron overload which is one of the predisposing factors to infe...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1778 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Abstract:
Beta thalassemia is an inherited hemoglobin disorder resulting in chronic hemolytic anemia that typically requires life long transfusion therapy. Repeated blood transfusions and RBCs hemolysis are the major causes of secondary iron overload which is one of the predisposing factors to infection in addition to immune abnormalities that occur in patients with ?- thalassemia. The aim of the work was to study T lymphocyte subsets in children with beta- thalassemia major and its correlation with iron overload. Methods: The present study was conducted on 20 children with beta thalassemia major under follow up at Hematology unit of Pediatric Department, Tanta university hospital in the period between December 2012 and July 2013 including 12 males and 8 females with mean age value of 9.22 + 3.9 and 20 healthy children as a control group including 11 males and 9 females with mean age value of 8.38 + 4.48. All children included in the study were subjected to the following investigations: Complete blood count, Hb electrophoresis, serum ferritin, serum iron, TIBC, CD3, CD4, CD8 levels and CD4/ CD8 ratio. Results: Hb, MCV and MCH were significantly lower while reticulocyte %, platelets and leucocytic count were significantly higher in patients than controls. Serum ferritin and iron were significantly higher but total iron binding capacity was significantly lower in patients than controls. CD3, CD4 and CD4/ CD8 ratio were significantly lower but CD8 was significantly higher in patients than controls. Conclusion: CD3, CD4 and CD4/CD8 ratio were significantly lower but CD8 was significantly higher in thalassemic patients compared with controls with negative correlation between CD3, CD4, CD4/CD8 ratio and iron overload and positive correlation between CD8 and iron overload. Recommendations: Regular follow up of thalassemic patients for detection of iron overload to avoid its complications as iron overload affect cell mediated immunity with reduction of CD3, CD4, CD4/CD8 ratio and elevation of CD8. |
|---|---|
| ISSN: | 2035-3006 |