Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis

Ursodeoxycholic acid alleviates aortic aneurysm and dissection through the intestinal farnesoid X receptor/ceramide synthase 2 axis

Abstract Aortic aneurysm and dissection (AAD) are severe cardiovascular conditions that carry significant risks and currently lack an effective treatment. Ursodeoxycholic acid (UDCA) can delay the onset of various metabolic diseases such as type 2 diabetes and obesity. However, it remains unclear wh...

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Main Authors: Zhaofeng Zhang, Linfeng Xie, Xinfan Lin, Jian He, Yuling Xie, Jiakang Li, Xinghui Zhuang, Lele Tang, Rumei Xie, Qingsong Wu, Zhihuang Qiu, Liangwan Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08403-2
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