Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study
BackgroundPatients with auditory verbal hallucination (AVH) may experience significant occupational and social functional disabilities, which bring a heavy burden to their families and society. Although neuroimaging studies have explored the brain regions associated with AVH and proposed models to e...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1559564/full |
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| author | Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Ju Tian Jiuju Wang Huiting Qiao Huiting Qiao Huiting Qiao Huiting Qiao Wenxiang Quan Yanping Song Daifa Wang Daifa Wang Daifa Wang Daifa Wang Wentian Dong |
| author_facet | Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Ju Tian Jiuju Wang Huiting Qiao Huiting Qiao Huiting Qiao Huiting Qiao Wenxiang Quan Yanping Song Daifa Wang Daifa Wang Daifa Wang Daifa Wang Wentian Dong |
| author_sort | Jiaxin Zhang |
| collection | DOAJ |
| description | BackgroundPatients with auditory verbal hallucination (AVH) may experience significant occupational and social functional disabilities, which bring a heavy burden to their families and society. Although neuroimaging studies have explored the brain regions associated with AVH and proposed models to explain AVH, the potential pathological mechanisms are not clear. Functional near-infrared spectroscopy (fNIRS) is a portable and suitable measurement, particularly in exploring brain activation during related tasks. Hence, our researchers aimed to explore the differences in the cerebral hemodynamic function between patients with schizophrenia with AVH (SZ-AVHs) and patients with schizophrenia without AVH (SZ-nAVHs) through fNIRS to examine neural abnormalities associated more specifically with AVH.MethodsA 52-channel functional near-infrared spectroscopy system was used to monitor hemodynamic changes in SZ-AVHs (n = 178) and SZ-nAVHs (n = 172) during a verbal fluency task (VFT). Clinical history, and symptom severity were also noted. The original fNIRS data were analyzed using NirSpark to obtain the brain functional eigenvalues including the integral value, which represents the degree of brain activation, and the centroid value, which represents the speed of blood oxygen response.ResultsOur results showed that the integral values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the left STC [t = 3.16, p = 0.014] while the centroid values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the right vlPFC [t = 2.78, p = 0.046].DiscussionOur findings indicate that SZ-AVHs exhibited lower activation in the left STC and Slower response speed in the right vlPFC than SZ-nAVHs. |
| format | Article |
| id | doaj-art-423381bfac3c4137b3f2da1157effa3f |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-423381bfac3c4137b3f2da1157effa3f2025-08-20T02:22:02ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15595641559564Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS studyJiaxin Zhang0Jiaxin Zhang1Jiaxin Zhang2Jiaxin Zhang3Jiaxin Zhang4Ju Tian5Jiuju Wang6Huiting Qiao7Huiting Qiao8Huiting Qiao9Huiting Qiao10Wenxiang Quan11Yanping Song12Daifa Wang13Daifa Wang14Daifa Wang15Daifa Wang16Wentian Dong17Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beihang University, Beijing, ChinaKey Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beihang University, Beijing, ChinaNational Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beihang University, Beijing, ChinaKey Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beihang University, Beijing, ChinaNational Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beihang University, Beijing, ChinaKey Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, Beihang University, Beijing, ChinaNational Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), Beihang University, Beijing, ChinaSchool of Biological Science and Medical Engineering, Beihang University, Beijing, ChinaPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, ChinaBackgroundPatients with auditory verbal hallucination (AVH) may experience significant occupational and social functional disabilities, which bring a heavy burden to their families and society. Although neuroimaging studies have explored the brain regions associated with AVH and proposed models to explain AVH, the potential pathological mechanisms are not clear. Functional near-infrared spectroscopy (fNIRS) is a portable and suitable measurement, particularly in exploring brain activation during related tasks. Hence, our researchers aimed to explore the differences in the cerebral hemodynamic function between patients with schizophrenia with AVH (SZ-AVHs) and patients with schizophrenia without AVH (SZ-nAVHs) through fNIRS to examine neural abnormalities associated more specifically with AVH.MethodsA 52-channel functional near-infrared spectroscopy system was used to monitor hemodynamic changes in SZ-AVHs (n = 178) and SZ-nAVHs (n = 172) during a verbal fluency task (VFT). Clinical history, and symptom severity were also noted. The original fNIRS data were analyzed using NirSpark to obtain the brain functional eigenvalues including the integral value, which represents the degree of brain activation, and the centroid value, which represents the speed of blood oxygen response.ResultsOur results showed that the integral values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the left STC [t = 3.16, p = 0.014] while the centroid values of the SZ-AVHs were significantly higher than those of the SZ-nAVHs in the right vlPFC [t = 2.78, p = 0.046].DiscussionOur findings indicate that SZ-AVHs exhibited lower activation in the left STC and Slower response speed in the right vlPFC than SZ-nAVHs.https://www.frontiersin.org/articles/10.3389/fneur.2025.1559564/fullschizophreniaauditory verbal hallucinationnear-infrared spectroscopyverbal fluency taskintegral valuecentroid value |
| spellingShingle | Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Jiaxin Zhang Ju Tian Jiuju Wang Huiting Qiao Huiting Qiao Huiting Qiao Huiting Qiao Wenxiang Quan Yanping Song Daifa Wang Daifa Wang Daifa Wang Daifa Wang Wentian Dong Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study Frontiers in Neurology schizophrenia auditory verbal hallucination near-infrared spectroscopy verbal fluency task integral value centroid value |
| title | Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study |
| title_full | Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study |
| title_fullStr | Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study |
| title_full_unstemmed | Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study |
| title_short | Alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia: a fNIRS study |
| title_sort | alterations in frontotemporal cerebral activity specific to auditory verbal hallucination during verbal fluency task in schizophrenia a fnirs study |
| topic | schizophrenia auditory verbal hallucination near-infrared spectroscopy verbal fluency task integral value centroid value |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1559564/full |
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