Dual inhibition of AKT and autophagy sensitizes triple negative breast cancer cells to carboplatin

Dual inhibition of AKT and autophagy sensitizes triple negative breast cancer cells to carboplatin

Triple-negative breast cancer (TNBC) exhibits the highest recurrence and mortality rates among breast cancer subtypes. Approximately one million TNBC cases are diagnosed worldwide annually. Current clinical treatments, primarily chemotherapy regimens based on paclitaxel and anthracycline, are associ...

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Bibliographic Details
Main Authors: Jun-zhen Zhou, Jing-ya Wen, Xin-wen Xu, Na Zhao, Jing-jing Tang, Ye-rui Xiao, Le-yang Xiang, Yue Jiang, Jian-wei jiang, Hong Hong, Qing Zhang
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Translational Oncology
Subjects:
EM-2
Breast cancer
Carboplatin
Autophagy
AKT
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325001652
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