Exploring the Non-Toxic Therapeutic Potential of <i>Dioscorea communis</i> in Combating Oral Pathogenic Bacteria and Their Effects on Hard and Soft Oral Tissues
<b>Background/Objectives:</b> Gingivitis and dental caries are oral diseases resulting from bacterial accumulation in dental plaque, leading to inflammation, tissue destruction and the demineralization of tooth structures. <i>Dioscorea communis</i>, due to its anti-inflammato...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/4/983 |
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| Summary: | <b>Background/Objectives:</b> Gingivitis and dental caries are oral diseases resulting from bacterial accumulation in dental plaque, leading to inflammation, tissue destruction and the demineralization of tooth structures. <i>Dioscorea communis</i>, due to its anti-inflammatory and antimicrobial properties, could be a new treatment candidate. <b>Methods:</b> This study evaluated the preventive and therapeutic effect of a <i>D. communis</i> berry juice paste, formulated at 3% and 7% concentrations, on gingivitis and dental caries, in 55 male SKH-hr2 hairless mice. Gingivitis and dental caries were induced by ligation of the upper left incisor and the paste was applied topically three times daily, five days a week. Treatment efficacy was assessed through clinical examinations, photo-documentation, histopathological analysis and FT-IR spectroscopy. <b>Results/Conclusions:</b> Preventive administration of <i>D. communis</i> 7% significantly delayed disease onset, while therapeutic effects on established conditions were limited. Both concentrations were non-toxic to gingival tissues and dental structures. |
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| ISSN: | 2227-9059 |