Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis
Background. To address the cause(s) of the significant differences in chloride (Cl-) concentrations between point-of-care blood gas analyzers and central laboratory analyzers. Methods. Cl- concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/768316 |
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| _version_ | 1832563212909805568 |
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| author | Tetsuya Makiishi Naomasa Nishimura Keiko Yoshioka Shinya Yamamoto Ryuichi Mitsuhashi Sayako Maeda Takashi Konishi Kunihiko Hirose |
| author_facet | Tetsuya Makiishi Naomasa Nishimura Keiko Yoshioka Shinya Yamamoto Ryuichi Mitsuhashi Sayako Maeda Takashi Konishi Kunihiko Hirose |
| author_sort | Tetsuya Makiishi |
| collection | DOAJ |
| description | Background. To address the cause(s) of the significant differences in chloride (Cl-) concentrations between point-of-care blood gas analyzers and central laboratory analyzers.
Methods. Cl- concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer (Hitachi7600) were collected in patients with severe acidemia (pH<7.20) (n=32) and were examined for correlations between differences in Cl- and factors associated with the acid-base status. Cl- concentrations were measured with both analyzers for samples with different concentrations of lactate, inorganic phosphate, or bicarbonate (HCO3 −).
Results. The differences in Cl- concentrations were correlated with HCO3 − concentrations (r=0.72, P<0.0001) and anion gap (r=0.69, P<0.0001). Only the addition of HCO3 − proportionately increased Cl- levels measured by a Hitachi7600, but it did not affect those measured by an ABL800FLEX.
Conclusion. Cl- measurements with some analyzers may be influenced by HCO3 − concentrations, which could result in the observed discrepancies. |
| format | Article |
| id | doaj-art-422ea8b8b97141948d6eab6591213653 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-422ea8b8b97141948d6eab65912136532025-02-03T01:20:42ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/768316768316Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic AcidosisTetsuya Makiishi0Naomasa Nishimura1Keiko Yoshioka2Shinya Yamamoto3Ryuichi Mitsuhashi4Sayako Maeda5Takashi Konishi6Kunihiko Hirose7Division of Nephrology, Department of Internal Medicine, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDepartment of Clinical Laboratory, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDepartment of Clinical Laboratory, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDivision of Nephrology, Department of Internal Medicine, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDepartment of Clinical Laboratory, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDivision of Nephrology, Department of Internal Medicine, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDepartment of Cardiology, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanDepartment of Cardiology, Otsu Red Cross Hospital, 1-1-35 Nagara, Shiga Otsu 520-8511, JapanBackground. To address the cause(s) of the significant differences in chloride (Cl-) concentrations between point-of-care blood gas analyzers and central laboratory analyzers. Methods. Cl- concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer (Hitachi7600) were collected in patients with severe acidemia (pH<7.20) (n=32) and were examined for correlations between differences in Cl- and factors associated with the acid-base status. Cl- concentrations were measured with both analyzers for samples with different concentrations of lactate, inorganic phosphate, or bicarbonate (HCO3 −). Results. The differences in Cl- concentrations were correlated with HCO3 − concentrations (r=0.72, P<0.0001) and anion gap (r=0.69, P<0.0001). Only the addition of HCO3 − proportionately increased Cl- levels measured by a Hitachi7600, but it did not affect those measured by an ABL800FLEX. Conclusion. Cl- measurements with some analyzers may be influenced by HCO3 − concentrations, which could result in the observed discrepancies.http://dx.doi.org/10.1155/2012/768316 |
| spellingShingle | Tetsuya Makiishi Naomasa Nishimura Keiko Yoshioka Shinya Yamamoto Ryuichi Mitsuhashi Sayako Maeda Takashi Konishi Kunihiko Hirose Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis International Journal of Nephrology |
| title | Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis |
| title_full | Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis |
| title_fullStr | Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis |
| title_full_unstemmed | Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis |
| title_short | Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis |
| title_sort | potential inaccuracies in chloride measurements in patients with severe metabolic acidosis |
| url | http://dx.doi.org/10.1155/2012/768316 |
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