Potential Inaccuracies in Chloride Measurements in Patients with Severe Metabolic Acidosis
Background. To address the cause(s) of the significant differences in chloride (Cl-) concentrations between point-of-care blood gas analyzers and central laboratory analyzers. Methods. Cl- concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/768316 |
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| Summary: | Background. To address the cause(s) of the significant differences in chloride (Cl-) concentrations between point-of-care blood gas analyzers and central laboratory analyzers.
Methods. Cl- concentrations measured simultaneously by a blood gas analyzer (ABL800 FLEX) and a central laboratory analyzer (Hitachi7600) were collected in patients with severe acidemia (pH<7.20) (n=32) and were examined for correlations between differences in Cl- and factors associated with the acid-base status. Cl- concentrations were measured with both analyzers for samples with different concentrations of lactate, inorganic phosphate, or bicarbonate (HCO3 −).
Results. The differences in Cl- concentrations were correlated with HCO3 − concentrations (r=0.72, P<0.0001) and anion gap (r=0.69, P<0.0001). Only the addition of HCO3 − proportionately increased Cl- levels measured by a Hitachi7600, but it did not affect those measured by an ABL800FLEX.
Conclusion. Cl- measurements with some analyzers may be influenced by HCO3 − concentrations, which could result in the observed discrepancies. |
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| ISSN: | 2090-214X 2090-2158 |