Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications: A Case Report and Literature Review
Lung cancer is still one of the most common malignant tumors in the world. With the increase of its incidence and the development of medical technology, the overall survival of lung cancer patients has significantly extended compared to before. The incidence of brain and meningeal metastases from lu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2025-03-01
|
| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2025.106.05 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849737556481015808 |
|---|---|
| author | Deng ZHANG Yiru KONG Xiaohua LIANG Xinli ZHOU |
| author_facet | Deng ZHANG Yiru KONG Xiaohua LIANG Xinli ZHOU |
| author_sort | Deng ZHANG |
| collection | DOAJ |
| description | Lung cancer is still one of the most common malignant tumors in the world. With the increase of its incidence and the development of medical technology, the overall survival of lung cancer patients has significantly extended compared to before. The incidence of brain and meningeal metastases from lung cancer has also been rising year by year, but patients with brain and meningeal metastases from lung cancer have a poor prognosis and a very high mortality rate, and the diagnosis is mainly based on computed tomography (CT), magnetic resonance imaging (MRI) and other imaging examinations. However, the imaging features are diverse and the specificity is low, which makes it easy to be misdiagnosed and missed. Therefore, accurately identifying brain and meningeal metastases and timely targeted treatment is crucial for improving patient prognosis. This paper analyzed the diagnosis and treatment of a case of lung cancer with no obvious recurrence and metastasis in nearly 7-year long-term follow-up after radical lung cancer surgery, but the patient with abnormal behavior, impaired consciousness and epilepsy in the past 5 months, and multiple punctate calcifications in the brain found by head CT and MRI. This paper consider that the patient's mental and behavioral symptoms were caused by brain and meningeal metastasis of lung cancer after excluding infectious disease and ineffective treatment of autoimmune encephalitis, and further pathological biopsy and genetic detection confirmed the diagnosis of metastatic lung adenocarcinoma with epidermal growth factor receptor (EGFR) L858R gene mutation, and the patient's symptoms were significantly improved after targeted therapy by Osimertinib. This paper also searched the relevant literatures of brain calcifications in databases such as China National Knowledge Infrastructure (CNKI), Wanfang, UpToDate, PubMed, etc., and found that intracerebral calcifications exist in a variety of diseases, including infectious, genetic and neurodegenerative diseases, vascular diseases, metabolic diseases and tumors. However, brain calcification in brain and meningeal metastases are often underestimated, and the consequent risk is misdiagnosis and delayed treatment. Therefore, brain and meningeal metastases manifested as brain calcification should not be ignored in patients with a history of previous tumors. |
| format | Article |
| id | doaj-art-422bbd593fa34b60ac0414ef746e0a8d |
| institution | DOAJ |
| issn | 1009-3419 1999-6187 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj-art-422bbd593fa34b60ac0414ef746e0a8d2025-08-20T03:06:53ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872025-03-0128323724410.3779/j.issn.1009-3419.2025.106.05Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature ReviewDeng ZHANG0Yiru KONG1Xiaohua LIANG2Xinli ZHOU3Department of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaDepartment of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, ChinaLung cancer is still one of the most common malignant tumors in the world. With the increase of its incidence and the development of medical technology, the overall survival of lung cancer patients has significantly extended compared to before. The incidence of brain and meningeal metastases from lung cancer has also been rising year by year, but patients with brain and meningeal metastases from lung cancer have a poor prognosis and a very high mortality rate, and the diagnosis is mainly based on computed tomography (CT), magnetic resonance imaging (MRI) and other imaging examinations. However, the imaging features are diverse and the specificity is low, which makes it easy to be misdiagnosed and missed. Therefore, accurately identifying brain and meningeal metastases and timely targeted treatment is crucial for improving patient prognosis. This paper analyzed the diagnosis and treatment of a case of lung cancer with no obvious recurrence and metastasis in nearly 7-year long-term follow-up after radical lung cancer surgery, but the patient with abnormal behavior, impaired consciousness and epilepsy in the past 5 months, and multiple punctate calcifications in the brain found by head CT and MRI. This paper consider that the patient's mental and behavioral symptoms were caused by brain and meningeal metastasis of lung cancer after excluding infectious disease and ineffective treatment of autoimmune encephalitis, and further pathological biopsy and genetic detection confirmed the diagnosis of metastatic lung adenocarcinoma with epidermal growth factor receptor (EGFR) L858R gene mutation, and the patient's symptoms were significantly improved after targeted therapy by Osimertinib. This paper also searched the relevant literatures of brain calcifications in databases such as China National Knowledge Infrastructure (CNKI), Wanfang, UpToDate, PubMed, etc., and found that intracerebral calcifications exist in a variety of diseases, including infectious, genetic and neurodegenerative diseases, vascular diseases, metabolic diseases and tumors. However, brain calcification in brain and meningeal metastases are often underestimated, and the consequent risk is misdiagnosis and delayed treatment. Therefore, brain and meningeal metastases manifested as brain calcification should not be ignored in patients with a history of previous tumors.http://dx.doi.org/10.3779/j.issn.1009-3419.2025.106.05lung neoplasmsbrain metastasesmeningeal metastasescalcificationctmri |
| spellingShingle | Deng ZHANG Yiru KONG Xiaohua LIANG Xinli ZHOU Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications: A Case Report and Literature Review Chinese Journal of Lung Cancer lung neoplasms brain metastases meningeal metastases calcification ct mri |
| title | Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature Review |
| title_full | Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature Review |
| title_fullStr | Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature Review |
| title_full_unstemmed | Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature Review |
| title_short | Brain and Meningeal Metastases of Lung Cancer Manifested as Brain Calcifications:
A Case Report and Literature Review |
| title_sort | brain and meningeal metastases of lung cancer manifested as brain calcifications
a case report and literature review |
| topic | lung neoplasms brain metastases meningeal metastases calcification ct mri |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2025.106.05 |
| work_keys_str_mv | AT dengzhang brainandmeningealmetastasesoflungcancermanifestedasbraincalcificationsacasereportandliteraturereview AT yirukong brainandmeningealmetastasesoflungcancermanifestedasbraincalcificationsacasereportandliteraturereview AT xiaohualiang brainandmeningealmetastasesoflungcancermanifestedasbraincalcificationsacasereportandliteraturereview AT xinlizhou brainandmeningealmetastasesoflungcancermanifestedasbraincalcificationsacasereportandliteraturereview |