Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism
Maternal Graves’ disease is relatively uncommon with an estimated incidence of 0.4%–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was...
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| Format: | Article |
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Wiley
2015-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/680191 |
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| author | Dimitrios Angelis Rita Ann Kubicky Alan B. Zubrow |
| author_facet | Dimitrios Angelis Rita Ann Kubicky Alan B. Zubrow |
| author_sort | Dimitrios Angelis |
| collection | DOAJ |
| description | Maternal Graves’ disease is relatively uncommon with an estimated incidence of 0.4%–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was born at 30-week gestation to a mother with Graves’ disease. Our patient presented with hyperthyroidism followed by transient hypothyroidism requiring treatment with levothyroxine. While hyperthyroid, she was treated with methimazole, iodine, and a beta-blocker. 20 days after the initiation of methimazole, she developed neutropenia. The neutrophil counts started to improve immediately after the initiation of the weaning of methimazole. To the best of our knowledge, this is the first case reported in the literature of methimazole induced neutropenia in a preterm infant being treated for neonatal Graves’ disease. |
| format | Article |
| id | doaj-art-422852b5a6d343728de76b8ec8fece76 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-422852b5a6d343728de76b8ec8fece762025-08-20T03:55:41ZengWileyCase Reports in Endocrinology2090-65012090-651X2015-01-01201510.1155/2015/680191680191Methimazole Associated Neutropenia in a Preterm Neonate Treated for HyperthyroidismDimitrios Angelis0Rita Ann Kubicky1Alan B. Zubrow2St. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USASt. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USASt. Christopher’s Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USAMaternal Graves’ disease is relatively uncommon with an estimated incidence of 0.4%–1% of all pregnancies, but only 1–5% of newborns delivered to mothers with Graves’ disease develop overt clinical signs and symptoms of hyperthyroidism. Here, we describe a case of a 1380-gram female neonate who was born at 30-week gestation to a mother with Graves’ disease. Our patient presented with hyperthyroidism followed by transient hypothyroidism requiring treatment with levothyroxine. While hyperthyroid, she was treated with methimazole, iodine, and a beta-blocker. 20 days after the initiation of methimazole, she developed neutropenia. The neutrophil counts started to improve immediately after the initiation of the weaning of methimazole. To the best of our knowledge, this is the first case reported in the literature of methimazole induced neutropenia in a preterm infant being treated for neonatal Graves’ disease.http://dx.doi.org/10.1155/2015/680191 |
| spellingShingle | Dimitrios Angelis Rita Ann Kubicky Alan B. Zubrow Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism Case Reports in Endocrinology |
| title | Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism |
| title_full | Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism |
| title_fullStr | Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism |
| title_full_unstemmed | Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism |
| title_short | Methimazole Associated Neutropenia in a Preterm Neonate Treated for Hyperthyroidism |
| title_sort | methimazole associated neutropenia in a preterm neonate treated for hyperthyroidism |
| url | http://dx.doi.org/10.1155/2015/680191 |
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