Orthogonal design-based investigation of dose, time point, and treatment course on the toxicity-efficacy transition of triptolide in collagen-induced arthritis mice

In recent years, the potential application of Tripterygium wilfordii Hook f. (TWHF) in the treatment of rheumatoid arthritis (RA) has garnered increasing attention in both academic research and clinical practice. However, the effective use of rheumatoid arthritis is limited in clinical practice by i...

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Bibliographic Details
Main Authors: Shuai Huang, Lu Xu, Yunzhe Wu, Kai Chen, Nan Sun, Zhe Feng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1622570/full
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