Tumor and α‐SMA‐expressing stromal cells in pancreatic neuroendocrine tumors have a distinct RNA profile depending on tumor grade

Tumor and α‐SMA‐expressing stromal cells in pancreatic neuroendocrine tumors have a distinct RNA profile depending on tumor grade

Alpha‐smooth muscle actin (α‐SMA) expression in the stroma is linked to the presence of cancer‐associated fibroblasts and is known to correlate with worse outcomes in various tumors. In this study, using a GeoMx digital spatial profiling approach, we characterized the gene expression of the tumor an...

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Bibliographic Details
Main Authors: Helvijs Niedra, Raitis Peculis, Rihards Saksis, Ilona Mandrika, Sofija Vilisova, Jurijs Nazarovs, Austra Breiksa, Aija Gerina, Julie Earl, Ignacio Ruz‐Caracuel, Marta Gabriela Rosas, Aldis Pukitis, Natalja Senterjakova, Vita Rovite
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Molecular Oncology
Subjects:
digital spatial profiling
gene expression
Pancreatic neuroendocrine tumors
pathway enrichment analysis
tumor stroma
Online Access:https://doi.org/10.1002/1878-0261.13727
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