Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination
Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds,...
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| Format: | Article |
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Wiley
2020-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/5054864 |
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| author | Farhad Ghanizadeh Gerayeli Farnaz Hosseini Zohreh Bagheri Amir Savardashtaki Zahra Shabaninejad Ali Mohammad Amani Sohrab Najafipour |
| author_facet | Farhad Ghanizadeh Gerayeli Farnaz Hosseini Zohreh Bagheri Amir Savardashtaki Zahra Shabaninejad Ali Mohammad Amani Sohrab Najafipour |
| author_sort | Farhad Ghanizadeh Gerayeli |
| collection | DOAJ |
| description | Zidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns. The AgNP λ-max peak was at approximately 405 nm. In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm. ZDV was determined in the range of 50–500 μM, and the detection limit value was obtained as 42 μM. The sensor was used to determine ZDV in tablets with good recovery. |
| format | Article |
| id | doaj-art-42218caa6099442dadfa415c4b7d9e09 |
| institution | Kabale University |
| issn | 1687-8760 1687-8779 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-42218caa6099442dadfa415c4b7d9e092025-02-03T05:44:12ZengWileyInternational Journal of Analytical Chemistry1687-87601687-87792020-01-01202010.1155/2020/50548645054864Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive DeterminationFarhad Ghanizadeh Gerayeli0Farnaz Hosseini1Zohreh Bagheri2Amir Savardashtaki3Zahra Shabaninejad4Ali Mohammad Amani5Sohrab Najafipour6Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Medical Biotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Nanotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, IranDepartment of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, IranZidovudine (ZDV) is an antiviral drug against HIV that was approved by the FDA on March, 1987. It is a reverse transcriptase inhibitor. This type of drug stops the reproduction of DNA and decreases the amount of the virus in the patients’ blood. Due to the ability of forming various molecular bonds, silver nanoparticles (AgNPs) are widely used for the detection of large range of agents, including drugs. In this study, we synthesized AgNP-modified β-cyclodextrin (β-CD) using green synthesis for the sensitive and selective zidovudine (ZDV) determination. Characterization of nanoparticles was done using different methods including infrared (IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and also, X-ray diffraction (XRD) patterns. The AgNP λ-max peak was at approximately 405 nm. In the presence of ZDV, yellow solution was turned to red color, and surface plasmon absorption band was dramatically centered at 560 nm. ZDV was determined in the range of 50–500 μM, and the detection limit value was obtained as 42 μM. The sensor was used to determine ZDV in tablets with good recovery.http://dx.doi.org/10.1155/2020/5054864 |
| spellingShingle | Farhad Ghanizadeh Gerayeli Farnaz Hosseini Zohreh Bagheri Amir Savardashtaki Zahra Shabaninejad Ali Mohammad Amani Sohrab Najafipour Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination International Journal of Analytical Chemistry |
| title | Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination |
| title_full | Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination |
| title_fullStr | Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination |
| title_full_unstemmed | Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination |
| title_short | Colorimetric Sensor Based on β-Cyclodextrin-Functionalized Silver Nanoparticles for Zidovudine Sensitive Determination |
| title_sort | colorimetric sensor based on β cyclodextrin functionalized silver nanoparticles for zidovudine sensitive determination |
| url | http://dx.doi.org/10.1155/2020/5054864 |
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