Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China
Abstract BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy‐confirmed cohort donated to a human brain bank in Beijing, China. METHODS A total of 483 subjects were neurop...
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Wiley
2025-04-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70100 |
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| author | Xiang‐Sha Yin Jianru Sun Xue Wang Wei Wu Zhen Chen Di Zhang Yuanyuan Xu Yongmei Chen Wenying Qiu Xiaojing Qian Jun Ni Chao Ma |
| author_facet | Xiang‐Sha Yin Jianru Sun Xue Wang Wei Wu Zhen Chen Di Zhang Yuanyuan Xu Yongmei Chen Wenying Qiu Xiaojing Qian Jun Ni Chao Ma |
| author_sort | Xiang‐Sha Yin |
| collection | DOAJ |
| description | Abstract BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy‐confirmed cohort donated to a human brain bank in Beijing, China. METHODS A total of 483 subjects were neuropathologically evaluated based on standardized protocols. Descriptive statistics and ordinal logistic regression models were used to estimate the correlation between CAA, AD, apolipoprotein E (APOE) genotyping, and cognitive function proximal to death. RESULTS Neuropathological assessment revealed that 53 of 483 subjects (11%) had CAA without AD, 78 of 483 (16%) had AD without CAA, 98 of 483 (20%) had both CAA and AD, and 254 of 483 (53%) had neither condition. A significant correlation was confirmed between CAA severity and AD. Subjects with both CAA and AD exhibited aggravated cognitive impairment. DISCUSSION Our results indicate a substantial prevalence of CAA that is frequently comorbid with AD and may exacerbate cognitive decline in the elderly population in China. Highlights First reporting of cerebral amyloid angiopathy (CAA) based on an autopsy‐confirmed cohort from China. The prevalence of CAA was high in the elderly Chinese sample. Age and apolipoprotein E (APOE) ε4 allele were related to the prevalence of CAA. CAA and Alzheimer's disease (AD) were frequently co‐occurred and significantly associated. Subjects with both CAA and AD exhibited aggravated cognitive impairment. |
| format | Article |
| id | doaj-art-4220fc9bce394b43b58fe38d9ee3a2e1 |
| institution | DOAJ |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-4220fc9bce394b43b58fe38d9ee3a2e12025-08-20T03:23:57ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-04-01172n/an/a10.1002/dad2.70100Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from ChinaXiang‐Sha Yin0Jianru Sun1Xue Wang2Wei Wu3Zhen Chen4Di Zhang5Yuanyuan Xu6Yongmei Chen7Wenying Qiu8Xiaojing Qian9Jun Ni10Chao Ma11Department of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaDepartment of Neurology State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaDepartment of Human Anatomy Histology and Embryology Institute of Basic Medical Sciences Neuroscience Center Joint Laboratory of Anesthesia and Pain Chinese Academy of Medical Sciences Peking Union Medical College Beijing ChinaAbstract BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy‐confirmed cohort donated to a human brain bank in Beijing, China. METHODS A total of 483 subjects were neuropathologically evaluated based on standardized protocols. Descriptive statistics and ordinal logistic regression models were used to estimate the correlation between CAA, AD, apolipoprotein E (APOE) genotyping, and cognitive function proximal to death. RESULTS Neuropathological assessment revealed that 53 of 483 subjects (11%) had CAA without AD, 78 of 483 (16%) had AD without CAA, 98 of 483 (20%) had both CAA and AD, and 254 of 483 (53%) had neither condition. A significant correlation was confirmed between CAA severity and AD. Subjects with both CAA and AD exhibited aggravated cognitive impairment. DISCUSSION Our results indicate a substantial prevalence of CAA that is frequently comorbid with AD and may exacerbate cognitive decline in the elderly population in China. Highlights First reporting of cerebral amyloid angiopathy (CAA) based on an autopsy‐confirmed cohort from China. The prevalence of CAA was high in the elderly Chinese sample. Age and apolipoprotein E (APOE) ε4 allele were related to the prevalence of CAA. CAA and Alzheimer's disease (AD) were frequently co‐occurred and significantly associated. Subjects with both CAA and AD exhibited aggravated cognitive impairment.https://doi.org/10.1002/dad2.70100Alzheimer's diseaseAlzheimer's disease neuropathologic changecerebral amyloid angiopathycognitive functionhuman brain bank |
| spellingShingle | Xiang‐Sha Yin Jianru Sun Xue Wang Wei Wu Zhen Chen Di Zhang Yuanyuan Xu Yongmei Chen Wenying Qiu Xiaojing Qian Jun Ni Chao Ma Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease Alzheimer's disease neuropathologic change cerebral amyloid angiopathy cognitive function human brain bank |
| title | Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China |
| title_full | Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China |
| title_fullStr | Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China |
| title_full_unstemmed | Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China |
| title_short | Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China |
| title_sort | prevalence of cerebral amyloid angiopathy and its correlation with alzheimer s disease and cognition in an autopsy confirmed cohort from china |
| topic | Alzheimer's disease Alzheimer's disease neuropathologic change cerebral amyloid angiopathy cognitive function human brain bank |
| url | https://doi.org/10.1002/dad2.70100 |
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