Enhancing the therapeutic efficacy of gemcitabine in bladder cancer through TGF-β1 inhibition and pluronic F-127-based microsphere delivery

Enhancing the therapeutic efficacy of gemcitabine in bladder cancer through TGF-β1 inhibition and pluronic F-127-based microsphere delivery

Abstract Bladder cancer is prevalent and features significant recurrence and progression rates, necessitating effective treatment strategies. Gemcitabine, commonly used to treat non-muscle invasive bladder cancer (NMIBC), shows moderate efficacy and notable side effects. TGF-β, not only a key in epi...

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Bibliographic Details
Main Authors: Yaoyao Xiong, Yangle Li, Lingxiao Chen, Minfeng Chen, Wei He, Lin Qi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Biological Engineering
Subjects:
Bladder cancer
Gemcitabine
TGF-β1 inhibitors
Microsphere
Drug-delivery system
Online Access:https://doi.org/10.1186/s13036-025-00535-7
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